高酸素および低酸素暴露時におけるラット肝臓中のレチノール, β-カロテンおよびα-トコフェロール量の変動

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When rats were exposed to hyperoxia (95% O_2) for 3 days, the content of α-tocopherol in the liver decreased significantly, whereas that of retinol did not change. Vitamin A deficiency did not show any effects on the decrease in α-tocopherol content with hyperoxia. Furthermore, the levels of thiobarbituric acid-reacting substances (an index of lipid peroxidation) and of 8-hydroxydeoxyguanine (a marker for the oxidative degradation of DNA) did not increase under the hyperoxic conditions even in the vitamin-A-deficient rats. When the vitamin-A-deficient rats were exposed to hypoxia (10.5% O_2 ; 5 days), the hepatic α-tocopherol content decreased significantly, although the α-tocopherol content did not change in the control rats. In contrast, the hepatic retinol content of the control rats decreased slightly with hypoxia. With β-carotene-supplemented rats, no change was observed in the hepatic α-tocopherol content under both the hyperoxic and hypoxic conditions, whereas the content of β-carotene in the liver tended to decrease under both conditions. The hepatic retinol content, which was significantly increased by β-carotene supplementation, also tended to decrease with hypoxia.
社団法人日本家政学会の論文
1998-11-15