Cytochrome c Oxidase Activity of Large Mitochondria Appeared in Osteoclasts during the Early Stage of Parathyroid Hormone Treatment
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概要
- 論文の詳細を見る
Large mitochondria that appeared in osteoclasts during the early stage of parathyroid hormone (PTH) treatment were examined histochemically and morphologically in order to elucidate how their appearance is related to ruffled border (RB) form or cytochrome c oxidase activity. Three types of osteoclasts including large mitochondria. that were characterized by closely packed cristae, appeared 1-2 hr after PTH treatment. The first type (PTH-1) showed a poorlydeveloped RB, and many large mitochondria concentrated on the basal membrane side. The second type (PTH-2) showed a welldeveloped RB. but the terminal infoldings did not expand. Many large mitochondria were scattered freely in PTH-2. The third type (PTH-3) showed a well-developed RB, and many expanded terminal infoldings and vacuoles could be seen in the RB. Large mitochondria in PTH-3 were few in number. Cytochrome c oxidase activities both in the control and in PTH-3 osteoclasts were significantly higher than that in the PTH-1 osteoclasts. Over 90% of large mitochondria showed high enzymatic activity. Only 0.7% of control osteoclasts had a cross-sectional mitochondrial area of over 0.867μm^2 (large mitochondria), whereas the area of over 0.867μm^2 was 4.7% of PTH-1,9% of PTH-2, and 2.3% of PTH-3 respectively. The present results suggest that large mitochondria demonstrate high ATP production, and that a close relationship exists between the location and number of large mitochondria and RB form during the early period when osteoclastic bone resorption is promoted by PTH.
- 日本組織細胞化学会の論文
著者
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Noda K
Department Of Orthodontics School Of Dental Medicine Tsurumi University
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Kuwahara Yosuke
Department Of Orthodontics Tsurumi University School Of Dental Medicine
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Kuwahara Yosuke
Department Of Orthodontics School Of Dental Medicine Tsurumi University
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Noda K
Tsurumi Univ. School Of Dental Medicine
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Nakamura Yoshiki
Department Of Neurosurgery National Hospital Organization Tokyo Medical Center
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Noda Koji
Department Of Accelerator And Medical Physics National Institute Of Radiological Sciences
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YOSHII Taeko
Department of Orthodontics, School of Dental Medicine, Tsurumi University
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Yoshii Taeko
Department Of Orthodontics School Of Dental Medicine Tsurumi University
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Nakamura Yoshiki
Department Of Built Environment Interdisciplinary Graduate School Of Science And Engineering Tokyo I
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Nakamura Yoshiki
Department of Orthodontics, School of Dental Medicine, Tsurumi University
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Kuwahara Yosuke
Department of Materials Science and Engineering, Meijo University, Nagoya 468-8502, Japan
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