実験的歯の移動時に出現した変性組織を吸収する異物巨細胞のチトクローム C オキシダーゼ活性の検出
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概要
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カルシウム(Ca)の代謝と密接な拘わりがあるアデノシン三燐酸(ATP)の生産器官である糸粒体を多数を有する異物巨細胞と破骨細胞との間にATP生産性の差が在るか否かについて, 実験動物にウイスターラットを用い, その指標的酵素であるチトクロームCオキダーセ活性を両巨細胞に検出し, 変性組織と骨に含まれるCa量の点から比較検討した.異物巨細胞は吸収構造の違いから, 波状縁構造のものと多様な細胞突起様構造を示す2つに分類された.酵素活性では2種類の異物巨細胞とも数多くの糸粒体が弱い反応を示していたのに対し, 破骨細胞では糸粒体のほとんどが強い酵素活性を示した.糸粒体に認められた酵素活性による反応産物の占める面積は細胞1μm^2当たり波状縁を有する異物巨細胞では0.0674μm^2, 細胞突起を有する異物巨細胞では0.0559μm^2, 破骨細胞では0.1098μm^2であり, 2種類の異物巨細胞の間には有為な差は認められなかったが, これら異物巨細胞と破骨細胞との間には有為な差が認められた.変性組織と骨のエックス線元素分析では骨は高いCaピークを示したのに対し, 変性組織は低いCaピークを示した.以上の結果から, 異物巨細胞はチトクロームCオキシダーゼ活性が低いことから低いATP生産性がうかがわれ, この低いATP生産性は変性組織中の低いCa含有量に対応し, 異物巨細胞による変性組織の吸収は低いエネルギーで生じる可能性が示唆された.
- 日本矯正歯科学会の論文
著者
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NAKAMURA Yoshiki
Department of Neurosurgery, National Hospital Organization Tokyo Medical Center
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野田 晃司
鶴見大学歯矯正学
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野田 晃司
Department of Orthodontics, School of Dental Medicine, Tsurumi University
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KUWAHARA Yosuke
Department of Orthodontics, School of Dental Medicine, Tsurumi University
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Kuwahara Yosuke
Department Of Orthodontics School Of Dental Medicine Tsurumi University
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Nakamura Yoshiki
Department Of Built Environment Interdisciplinary Graduate School Of Science And Engineering Tokyo I
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Kuwahara Yosuke
Department of Materials Science and Engineering, Meijo University, Nagoya 468-8502, Japan
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