Renoscintigram の研究

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I. Basic Study. Experiments were performed for the following purposes: (1) to determine the distribution of RI-Neohydrin (^<203>Hg and ^<197>Hg-Neohydrin) in the body, (2) to investigate the radiation effects of RI-Neohydrin on the kidneys and (3) to evaluate the tracing ability of the Renoscintigram by means of phantome experiment. (l) The rabbits were divided into 10 groups and 30 μCi of ^<203>Hg-Neohydrin were administered intravenously to each of the rabbits. Then the rabbits were sacrificed in 5 minutes, 30 minutes, 1 hour, 2 hours, 3 hours,12 hours, 1 day,7 days,21 days and 30 days. The animals were autopsied immediately after sacrifice. The various organs were counted for radiation (count/min./mg). Autoradiography was done to illustrate the distribution of Neohydrinin the kidney. (2) The rabbits were divided into six groups by the doses administered ^<203>Hg-Neohydrinl,3and 10μCi/kg,^<197>Hg-Neohydrin 3,10 and 50μCi/kg) and the results were compared with that of the control group with 1.95 mg of plain Neohydrin. The animals were sacrificed in 2nd, 5th,1 week, 3 weeks,7 weeks and 21 weeks following the administration and the kidneys were removed immediately for the studies. (3) The scintiscanning procedures were performed using kidney phantoms containing 50μCi of a ^<203>Hg -Neohydrin each and with the cavities of 1 cm, 2 cm, 3 cm and 4 cm in diameter. The scintiscanner (AlokaJSS-103B) was equipped with a cut off system as a background eraser. The scanning was performed with cut off level at 40-80 %.
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Renoscintigram の研究

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