β-N-アセチルグルコサミニダーゼインヒビターであるN-アセチルグルコサミノラクトンのStreptomycesとAspergillusの生育に対する影響

概要

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N-Acetylglucosaminolactone(lactone)strongly inhibited the action of N-Acetylglucosaminidase(GlcNAcase)produced by Streptomyces flaveorus and Aspergillus niger. The effects of the lactone on the growth of these organisms were examined to elucidate the physiological role of the enzyme. In colony count and growth-inhibiting zone determination experiments, it was found that a certain concentration of the lactone suppressed the growth of S. flaveorus, but did not have any inhibitory effect on the growth of A. niger. It therefore appears that the action of GlcNAcase is essential for the growth of S. flaveorus. Heating the lactone at 115℃ in 0.2% potassium phosphate solution or a medium containing the compound significantly destroyed its inhibitory activity; it is thus necessary to select a suitable medium for investigation of the lactone.
社団法人日本生物工学会の論文
1994-01-25