光学活性固定相を用いる有機チオリン酸アミドの光学異性体のガスクロマトグラフ分離

概要

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The gas chromatographic resolution of enantiomers of organophosphoramidothioate containing an asymmetric phosphorous atom on a chiral stationary phase has been succeeded, and the satisfactory results were obtained. For example, (±)-O-ethyl-O- (2-nitro-5-methylphenyl)-N-isopropylphosphoramidothioate was resolved within about 2.3 h at 180℃ on a 60 m × 0.25 mm glass capillary open tubular column coated with N, N'-[2, 4-(6-ethoxy-1,3, 5-triazine) diyl]-bis-(L-valyl-L-valyl-L-valine isopropyl ester). Consequently, the optical purity of this compound, which is known as a herbicide, can be easily determined from the ratio of the resolve.d peak areas. It is noticeable that organophosphoramidothioates, containing no asymmetric carbon atoms, have been resolved on an optically active stationary phase containing only asymmetric carbon atoms.
社団法人日本分析化学会の論文
1979-01-05