光学活性固定相を用いるガスクロマトグラフィーによるアルコール光学異性体の直接分離

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Direct separation of some alcohol enantiomers by gas chromatography with optically active stationary phases. Naobumi Oi, Tadashi Doi, Hajimu KITAHARA and Yoko INDA (Institute for Biological Science, Sumitomo Chemical Co., Ltd., 4-2-1, Takatsukasa Takarazuka-shi, Hyogo) The enantiomers of some chiral alcohols were directly separated for the first time by gas chromatography with optically active stationary phases. For example, racemic 1-phenylethanol was resolved (α = 1.016) on a opentubular glass capillary column (95 m ×0.25 mm i.d.) coated with N, N', N"-[2,4,6-(1,3,5-triazirie)triyl]-tris-(N^α-lauroyl-L-lysine-t-butylamide) at 100 ℃. The S-isomer was eluted prior to R-isomer. It is to be noted that these chiral alcohols are the first enantiomers separated by gas chromatography that possess a free hydroxyl function directly linked to the asymmetric carbon atom, except for the case of a-hydroxy carboxylic acid ester enantiomers. (Received Sept. 3, 1980)
社団法人日本分析化学会の論文
1981-01-05