光学活性固定相を用いる高速液体クロマトグラフィーによる遊離α-メチルアリール酢酸光学異性体の直接分離(<特集>医薬品の分析)

概要

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Direct enantiorneric separation of α-methylarylacetic acid anti-inflammatory agents has been studied by high performance liquid chromatography with a chiral stationary phase, N-3, 5-dinitorobenzoyl-(R)-phenylglycine chemically bonded to aminopropyl silica gel. Enantiomers of fenoprofen, ketoprofen and pranoprofen were separated with good separation factors (α=1.06, 1.05 and 1.04). It is very noticed that these α-methylarylacetic acid enantiomers can be separated without any pre-derivatization such as amidation or esterification. These results suggest that enantiomers of another aromatic carboxylic acid may be also resolved directly with this chiral stationary phase.
社団法人日本分析化学会の論文
1986-03-05