水熱ホットプレス環境下でのアミノ酸の脱水縮合

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Hydrothermal hot-pressing environments could be simulated as possible environments for chemical evolution toward polymerization of amino acids because the environments could possess high-pressure and high-temperature conditions, resulting from the dynamics of plate tectonics. We attempted the dehydration condensation of amino acids under hydro-thermal hot-pressing environments. A solid mixture of the starting materials, amino acids and inorganic materials, was sealed without water in an autoclave tube, and then treated under hydrothermal hot-pressing conditions. The pressure was 58.6 MPa and the temperature increased by 10℃/min from room temperature to 270℃; the duration times were 12 and 36 h. After the reaction, the product was granulated and dispersed in water by ultrasonication, and them centrifuged. Dipeptides, such as Gly-Gly and Phe-Phe in the aqueous parts from the starting glycine and phenyalanine, respectively, in the presence of silica gel or sodium carbonate were identified by the HPLC and LC/MS-SIM method. Their yields were approximately from 1.2 to 1.9%. Furthermore, an analysis of the solid parts by FT-IR obviously showed the formation of peptide compounds on a solid surface. An elemental analysis of the same solid parts showed the formations of oligomers, such as dimer and trimer of the starting amino acids. Under these experimentals hydrothermal hot-pressing environments could be concidered to be ideal sites for the abiogenic dehydration condensation of amino acids. Also the coexistence of some inorganic materials would be essential for the dehydration polymerization of amino acids.
1998-05-05

水熱ホットプレス環境下でのアミノ酸の脱水縮合

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