高温・高圧環境下における核酸塩基の化学進化に関する研究

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Chemical Evolution of Nucleic Acid Bases under High Temperature and High Pressure Environments Keiji GAMOH and Hiroki MINAMI Chemistry Division, Faculty of Education Hydrothermal hot-pressing environments could be simulated as possible environments for chemical evolution toward condensation of nucleic acid bases and ribose because the environments could possess high pressure and high temperature conditions, resulting from the dynamics of plate tectonics. We attempted the dehydration condensation of nucleic acid bases and ribose under hydrothermal hot-pressing environments. A solid mixture of the starting materials, nucleic acid bases, ribose and inorganic materials, was sealed in an autoclave tube, and then treated under hydrothermal hot-pressing conditions. The pressure was 450 kg/cm^2 and the temperature increased by 10℃/min from room temperature to 200 ℃: the duration times were 1 to 40 hours. After the reaction, the product was granulated and dispersed in acetate buffer (pH 4.5) by ultrasonification, and then centrifuged. The analysis of the aqueous extract was proceeded by high performance liquid chromatography (HPLC) and liquid chromatography/mass spectrometry (LC/MS). Condensation products in the aqueous parts from starting adenine and ribose mixture in the presence of silica gel and/or kaolinite were observed by the liquid chromatographic method. Their yields were approximately from 0.5 to 1.8 %. Under these experimentals hydrothermal hotpressing environments could be considered to be ideal sites for the abiogenic dehydration condensation of nucleic acid bases and ribose. Also the coexistence of some inorganic materials would be essential for the dehydration condensation of them.
2002-12-25

高温・高圧環境下における核酸塩基の化学進化に関する研究

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