ラットにおけるトリプトファン,アソスラニル酸および3-ヒドロキシアンスラニル酸のナイアシン活性

概要

論文の詳細を見る
The nutritional and biological efficiency of tryptophan, anthranilic acid, and 3-hydroxyanthranilic acid as a substitute for nicotinic acid was investigated by using weanling rats fed with a nicotinic acid-free, tryptophan-limiting diet (basal diet ; negative control), basal diet containing 0.003% nicotinic acid (positive control), 0.1% tryptophan, 0.1% anthranilic acid, or 0.1% 3-hydroxyanthranilic acid. Of these three compounds, tryptophan and 3-hydroxyanthranilic acid had an activity for growth promotion, the increases in the concentrations of NAD and total nicotinamide, but anthranilic acid did not. The sum of the urinary excretion of nicotinamide and its metabolites was compared between the groups of nicotinic acid and tryptophan, and between the groups of nicotinic acid and 3-hydroxyanthranilic acid. As the results, tryptophan was approximately 1/6 as active as nicotinic acid in molar basis, and 3-hydroxyanthranilic acid 1/10 in molar basis.
日本ビタミン学会の論文
1994-10-25