ペニシリン吸著に關する研究

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We investigated the adsorption of penicillin with activated carbon, and obtained the following results.It is generally recognized that penicillin is adsorbed in accordance with the Freundlich' adsorption isothermal equation.In the penicillin broth containing ca. 200〜300 u/cc. about 99% of penicillin is adsorbed by using 1.0-1.5% of activated carbon.The adsorption equilibrium in penicillin broth is reached in a short time. In practise, penicillin is almost adsorbed in ca. 10-20 min.The manner of adding carbon has no remarkable effect on the adsorption of penicillin.If a certain amount of carbon is used 2 or 3-times, filtering in each case, the amounts of carbon can be decreased.For example, if 0.5% of carbon are added two times to the 263 u/cc. penicillin broth 99% of penicillin is adsorbed.As described in the following experiments, when first 1.5% and next 0.5% (namely 2%) of carbon are used, 99% of penicillin is adsorbed even when it is of higher potency (ca. 1000 u/cc).
公益社団法人日本生物工学会の論文
1949-08-15