微生物による炭化水素の利用に関する研究 : (第5報)炭化水素を原料とするα-ケトグルタール酸の発酵生産

概要

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Among the hydrocarbon utilizing bacteria previously reported by the authors to be capable of producing amino acids, several strains were found to be richly productive of α-ketoglutaric acid from n-alkanes. The yield of the acid by these strains was more than 40% of the consumed hydrocarbons. Particularly, Corynebacterium sp. (KY 4439) was the highest in productivity. Additions of corn steep liquor and thiamine at suboptimal concentrations together with appropriate amounts of Fe^(++) and trace metal ions were effective for the production of α-ketoglutaric acid. To keep the pH under control between 6.7 and 7.0 by feeding NH_4OH was also contributive. The production ratio to the consumption hydrocarbons was increased by the lowering of the concentration of hydrocarbons in the medium. With an addition of 8.7% (v/v) of n-paraffins the acid yield reached as high as 85.5%.
社団法人日本生物工学会の論文
1969-05-25