トリプトファン-ナイアシン代謝経路の中間体とニコチン酸類縁化合物のナイアシン活性効率

概要

論文の詳細を見る
The nutritional efficiencies of the intermediates of the tryptophan-niacin pathway and the related compounds of nicotinic acid and nicotinamide as a substitute for nicotinic acid were investigated using weanling rats fed the niacin-deficient diet. Judging from the growth response, levels of liver NAD, blood NAD, and urinary excretion of nicotinamide and its metabolites, we have concluded that tryptophan, 3-hydroxyanthranilic acid, quinolinic acid, nicotinamide N-oxide, N'-methylnicotinamide, nicotinuric acid, 3-acetylpyridine, pyridine 3-aidehyde, pyridine 3-methanol, β-picoline, or nicotinic acid N-oxide is approximately 1/10, 1/12, 1/24, 1/5, 1/2, 1/10, 1/10, 1/1, 1/1, 1/10, or 1/2 active as nicotinic acid, however, that N-formylkynurenine, kynurenine, 3-hydroxykynurenine, anthranilic acid, cinchomeronic acid, 3-cyanopyridine, 6-hydroxynicotinic acid, and pyridine 3-sulfonic acid do not have any niacin activity. Only 6-aminonicotinamide of the examined compounds showed the very strong antagonistic activity against niacin.
1998-10-25