高酸素濃度下における発酵生産と微生物増殖の制御

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In aerobic culture, microbial production and cellular growth depend on the concentration of dissolved oxygen (DO). However, there have been few studies on the cultivation under high concentraiton of DO because significant inhibition of microbial growth by high DO concentraitons has been emphasized.In this paper, the following topics are disscussed to elucidate the effects of high concentration of DO on microbial production and cellular growth.1. Citric acid production by Candida tropicalis under high DO concentration was studied. The optimum DO concentraiton for the production of citric acid was around 60 ppm, although the cellular growth at this DO level decreased to about one half of that at 6 ppm.2. The rate of gluconic acid production by Aspergillus niger increased with increasing DO concentration, and no inhibitory effect was observed even at the DO of 150 ppm.3. The cellular growth and activities of a strain of Pseudomonas aeruginosa were examined at DO concentrations of 7.5-90 ppm. The cellular yield decreased with increasing DO concentraion, although the activity of the cells in consumption of organic substrates was not affected by DO concentration.4. Experiments were done to identify the operating conditions decreasing the excess sludge in a deep aeration column under periodic changes in DO concentration. The conditions of operation aiming at lowering cellular yield, which is closely related to the amount of the excess sludge, were found to be in the range of 1-2 min per cycle.5. Protection of a bioreactor from microbial contamination was studied. Proliferation of microbial contaminants in bioreactors could be satisfactorily suppressed by maintaining a high DO concentration.
公益社団法人日本生物工学会の論文
1990-09-25

高酸素濃度下における発酵生産と微生物増殖の制御

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