アルキルアミノ酸, アミノ酸アルキルエステル, アミノ酸アルキルアミドの生分解性 : 微生物によるアミノ酸誘導体の生分解に関する研究(第2報)

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A systematic study was made on biodegradability of N-alkyl amino aids, amino acid-alkyl esters, and amino acid-alkyl amides.The amino acid derivatives mainly tested here, N-alkyl-L-valine, L-glutamic acid-alkyl ester, and L-glutamic acid-γ-alkyl amide showed a high degree of biodegradability. The effects of alkyl carbon chain length, the kind of amino acid and the initial pH of cultivation on biodegradation were examined. The results were as follows : 1) The rate of biodegradation tended to decrease for lower alkyl (C_6-C_8) groups of alkyl-L-valines, and for higher alkyl (C_<12>-C_<18>) groups of L-glutamic acid-γ-alkyl amides, L-Glutamic acid-alkyl esters (mono-, di-ester) showed a high degree of biodegradability irrespective of the alkyl carbon chain length.2) The kind of amino acid had no effect on biodegradability, but the position of the alkyl radical on the amino acid did effect the rate of biodegradation.3) Thought an alkalie initial pH tended to lower the rate of biodegradation of the amino acid derivatives, the biodegradability after 14days cultivation was almost equal to that with neutral initial pH.The rate of biodegradation (period required for 25% of theoretical oxidation) and antimicrobial activity showed good correlation in the same strains.
社団法人日本生物工学会の論文
1977-01-25