N-長鎖アシルアミノ酸の化学構造と生分解性 : 微生物によるアミノ酸誘導体の生分解に関する研究(第1報)

概要

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A systematic study was made on the relation between biodegradation and chemical structure of long chain N-acyl amino acids.The N-acyl amino acids tested here, N-acyl-L-valine, N-acyl-L-glutamic acid and N-acyl-L-lysine, showed a high degree of biodegradability. Average values of 85-95% were obtained after 14 days cultivation. Biodegradability of N-acyl amino acids generally showed almost the same value as the fatty acid which constituted the individual acyl anino acids.Biodegradative patterns of unsaturated fatty acids and of N-acyl-L-glutamic acid with the corresponding unsaturated fatty acid radicals were closely similar. Therefore, the rate of biodegradation was limited by the degree of unsaturation of the fatty acid radical.The kind of amino acid (valine, glutamic acid, lysine) and their stereoisomerism(L, D, and DL forms) did not effect the biodegradability of N-acyl amino acids.In the biodegradation of N-acyl-L-lysine, N-acyl radical was first split from amino acid. The acyl radical at th N^δ position was removed more rapidly than that at the N^αposition.The rate of biodegradation of N-acyl amino acids was expressed as the period required for 25% of theoretical oxidation, and was compored with those of commercial surfactants.
社団法人日本生物工学会の論文
1976-05-25