實驗的高血壓症の研究 (第2報) : Phlorrhizin, 2,4-Dinitrophenol, 酪酸等

概要

論文の詳細を見る
It is suggested that the disturbance of carbohydrate metabolism refers to the development of hypertension such as diabetics may be attended with hypertension. Phlorrhizin. 2. 4-dinitrophenol (DNP) and butyric acid were used to produce the patterns of the hypertension concerned in such metabolic disturbance.The results obtained were as follows : 1) Hypertension did not occur in the rats, in which glucose loading was given in a dosage just enough to produce glucosuria for the experimental production of the patterns of diabetic hypertension. When an increased dose of phlorrhizin was given every day in a quantity just enough to produce glucosuria, the blood pressure increased moderately in all rats to 140-150 mmHg. Loading with butyric acid or leucine led to further elevation of the blood pressure.2) The effects of DNP, which involves the disturbance of metabolism in whole body, on blood pressure were also observed. No remarkable change was produced on the blood pressure by DNP administration. The change in the kidney was slight. However, the necrotic fall of the peripheral body tissue was observed in rabbits and rats.3) It is said that butyric acid may be produced in the intermediary process of the fat metabolism. Accordingly, the pressor effect of this compound was studied. In long-term experiment, the blood pressure was moderately elevated in most cases. When some animals showed no elevation of blood pressure, they were subjected to a loading with leucine, and then the blood pressure rose slightly. The necrotic fall of the tail was observed in rats.4) Such pressor substances as phlorrhizin, butyric acid and leucine caused tachphylaxis in the animals.From the above results, it seems without a doubt clear that the disturbance of metabolism is responsible for hypertension. But such degree of slight and not strictly specific metabolic disturbance as was induced in the experimental animals in the present study by means of phlorrhizin and other chemical substances, was not striking enough in its effect to yield a satisfactory result, because the living oranisms were capable of adaptation. The truth is that these chemical substances constitute neither necessary nor sufficient condition for hypertension.
社団法人日本循環器学会の論文
1958-09-20

實驗的高血壓症の研究 (第2報) : Phlorrhizin, 2,4-Dinitrophenol, 酪酸等

スポンサーリンク

概要

著者

関連論文

スポンサーリンク