食鹽高血壓に關する實驗的研究(第2報) : 長期食鹽高血壓
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Using male albino rats, I succeeded in the development of a longterm salt-hypertension (duration, 192-272 days). As the previous report, I investigated various clinical observations, particularly such as sodium chloride metabolism.Salt-loading consisted in the substitution of sod. chloride solution (1-1.5-2.0 %) for the drinking water, and in injection of a 2 % sod. chloride sol. into the abdominal cavity or diets high in sod. chloride (0.2-0.3-0.4g. per day). The increase of this loading was gradually performed.In the course of chronic high salt-loading, the blood pressure levels of the rats exceeded over 200 mm of Hg.In some other rats the elevated blood pressure returned gradually to the control values after cessation of the salt loading.The maximum water intake was 77.2 cc. per 100 g. body weight per day.No increase of N. P. N. in blood was observed, however a transient proteinuria was sometimes found.There was no relationship between urinary output of 17-KS and elevation of blood pressure through this experiment.The changes in the administered salt levels are surely reflected to the increase 17-KS output in urine, presumably as a consequence of any type of stress.The excessive retention of sod. was showed by the investigations of sod. content in serum or muscle and sod. chloride metabolism.The relationship between the elevation of blood pressure and the amount of NaCl retention seems to be proportional.
- 社団法人日本循環器学会の論文
- 1956-02-20
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