食鹽高血壓に關する實驗的研究(第3報) : 考按並びに總括

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In this report, I described discussion and summary about the previous papers (I & II). DCA hypertension is very similar to salt hypertension is very similar to salt hypertension in regards to through the intermedium of sod. chloride.Then, in the both experimental hypertension, the elevation of blood pressure was always observed after the retention of sodium.the important differences in sod. chloride metabolism between DCA rats and NaCl-loading rats were showed to be significant in comparison of the mean or the maximum sod. chloride intakes volume.These differences may be dependent upon the salt-retaining properties of DCA, and so DCA hypertension did not need sod. chloride so mach as salt hypertension in rats.The changes of the adrenal cortex were similar in both DCA-and salt-hypertensive rats (particularly, chronic NaCl-loading rats), namely atrophy of zona glomerulosa and sligh hyperfunction of zona fasciculata.The above results suggest the following view, that sodium may be essential for the pathogenesis of hypertension.
社団法人日本循環器学会の論文
1956-02-20