酪酸による實驗的高血壓の研究

概要

論文の詳細を見る
Ketone bodies as β-hydroxybutyric acid increase frequently in diabetes mellitus, and butyric acid may be produced in the intermediate products of fat metabolism and increase in diabetes. As diabetes is frequently attended with hypertension, it seems that the disturbance of metabolism is related to the development of hypertension. From this point of view, the author researched for the cause of hypertension by producing experimentally the pattern of diabetes, and then investigated the pressor effect of butyric acid, which were injected into normal and preessoreceptor denerved dogs, and furtheremore injected butyric acid intravenously for long time in order to produce sustained hypertension.(1) 200 mg. of butyric acid was injected into vein or pulmonary artery of two normal anesthetized dogs. By the first administration, butyric acid unconstant reaction in systemic blood pressure (mean), which was pressor or depressor. By the second administration, butyric acid showed no remarkable changes in systemic pressure. Butyric acid had a slight depressor or pressor effect in pulmonary pressure (mean).(2) 200 mg. of butyric acid was injected into vein or pulmonary artery of five anesthetized dogs, whose buffer nerves had been sectioned off, because such dogs react sensitively to pressor substances. Butyric acid had pressor effect of 6-54 mmHg in systemic blood pressure (mean) at 10 of 13 times, but had depressor effect of 10-24 mmHg at 3 times. The second and third administration of butyric acid had less pressor effect than the first administration, perhaps due to socalled tachyphylaxis. Butyric acid had pressor effect of 2-8 mmHg in pulmonary pressure (mean).(3) In order to produce sustained hypertension experimentally, 10-40 mg. of butyric acid was repeatedly injected intravenously into two normal dogs, which were given orally with 0.25-0.5 mg of atropine sulphate for a time. The blood pressure did not rise in one dog, but in another it was elevated to 160-180 mmHg and sustained. Histologic changes in kidney were marked, simulating the changes in experimental renal hypertensive animals. These changes were founed in two dogs, with or without hypertension, suggesting that these renal lesions were not proportional to the degree of hypertension.These experiments showed that the disturbance of metabolism played an important role in the development of hypertension, but specific metabolic disturbance induced by a chemical substance as butyric acid were not sufficient to yield satisfactory results. Therefore Professor Maekawa postulated a new theory that the true cause of hypertension might be disturbances of the ATP-ATPase system of cardiovascular system, from his extensive experimental and clinical studies.
社団法人日本循環器学会の論文
1959-10-20

著者

豊田重市
京都大學醫學部内科學第三講座

酪酸による實驗的高血壓の研究

スポンサーリンク

概要

著者

関連論文

スポンサーリンク