腎Adenosinetriphosphataseによる實驗的高血壓の研究(第3報) : 鼠腎Adenosinetriphosphatase靜脈内連續投與
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In previous report the Kidney-ATPase was injected intraperitoneally and subcutaneously into albino rats repeatedly, but the blood pressure did not rise. In this report the Kidney-ATPase was therefore injected into tail vein of rats.(1) The crude Kidney-ATPase was injected repeatedly in 45 rats. There were only 14 rats (4 normal and 10 uninephrectomized) which were injected more than 13 times, because the others died by shock after intravenous administration of the Kidney-ATPase, got the necrosis of tail or died by illness during the experiment.a) In 3 of 4 normal rats treated with 1% NaCl, the blood pressure was elevated moderately, because the crude Kidney-ATPase was injected intravenously more repeatedly, but their blood pressure had a tendency to fluctuate. Histologic changes in kidney were slight.b) Of 10 uninephrectomized rats treated with 1% NaCl, the blood pressure was elevated temporary or not in 3,elevated morderately or slightly in 2,and elevated markedly in 5. In 2 of these rats, the pressure remained hypertensive at about 200 mm. Hg. even after withdrawal of injections as in post-DCA-hypertension. Histologic changes in kidney revealed exudation into Bowman's capsule, degeneration of tubuli, hyaline casts and cell infiltration. These changes were marked in rats with severe hypertension and slight in other animals. No atheromatous changes in coronary artery in and aorta were found in rats treated with ATPase and cholesterol for a long time.c) 26 rats died by snock after intravenous administration of the crude Kidney-ATPase. At autopsy hemorrhagic exudate in the abdominal cavity was found in many rats, and small hemorrhage in intestine, lung and stomach in some rats.(2) The Kidney-ATPase semi-purified with Alumina Cream C_γ (fraction C and K) is possible to be given intravenously more safely than the crude Kidney-ATPase. Semi-purified ATPase was injected repeatedly into 4 uninephrectomized rats with 1% NaCl, and the blood pressure was elevated moderately during injecticns, but did not sustain after withdrawal of injections. Histologic changes in kidney showed atrophy of glomeluli, degeneration of tubuli, hyaline casts and cell infiltration in the interstitium.
- 社団法人日本循環器学会の論文
- 1959-09-20
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