腎Adenosinetriphosphataseによる實驗的高血壓の研究(第2報) : 粗腎Adenosinetriphosphatase腹腔内並びに皮下連續投與

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The author described in the previous report that the crude Kidney-ATPase (fraction W) extracted from rats with Weber-Edsall's solution had marked and sustaining pressor effects in both systolic and diastolic pressure, when it was injected into anesthetized rats. This experiment was performed to produce sustained hypertension in rats by repeated administrations of Kidney-ATPase.(1) The Dog-Kidney-ATPase (3-1 cc) was injected into the abdominal cavity of 6 rats for 10-11 days, but the blood pressure was not elevated. In a few days the tails of rats became edematous, hemorrhagic and ulcerated. When the crude Kidney-ATPase was furtheremore injected in succession, general condition of animals became worse and their tails became necrotic at the same time. Histologically, the author found edematous and necrotic changes in tails, hemorrnage in the media of tail artery in two rats, but changes in kidney were slight.(2) In order to avoid allergic reactions, the crude Rat-Kidney-ATPase (1-3 cc) was injected into abdominal cavity of 6 rats for 26 days, and then with an interval of 15 days injected subcutaneously 4 of 6 rats for 15 days, but the blood pressure had not elevated. The histologic changes in kidney were slight. Capillary bleeding, cell infiltration and degeneration of heart muscle were found in the hearts of 3 rats, which showed edema and bleeding in the end of tails. The fact suggests that an intimate relation consists in pathological changes between the heart and tail.These two experiments revealed that the crude Kidney-ATPase had a vasotoxic factor besides the pressor factor.
社団法人日本循環器学会の論文
1959-08-20

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豊田重市
京都大學醫學部内科學第三講座

腎Adenosinetriphosphataseによる實驗的高血壓の研究(第2報) : 粗腎Adenosinetriphosphatase腹腔内並びに皮下連續投與

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