筋腫心臓の成因に關する研究(第4報)
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At this experiment, male rabbits were injected with the phosphatide pf uterine muscle or ovahormon (estrogen) before the sensitization by oxen-sera. In 3 weeks after the sensitization by oxen-sera, all animals were reinjected with the mixture of oxen-sera and myom-phosphatide. During this experiment, clinically, blood-pressure, urine, blood, and electrocardiogram was examined. Afterwards, animals were killed and their organs were investigated histologically. These clinical examinations revealed no remarkable change except the hypothrombocytemia and the lowering of T wave electrocardiographically in some animals after the reinjection. Histologically, hearts of male animals which were injected with the phosphatide of uterine muscle, showed the allergic myocarditis consisting of moderate cell-infiltrations and periarteriolitis, and hearts of animals which were injected with the ovahormon showed also the similar allergic myocarditis of more slightly degree. But, in comparison of changes of hearts in female rabbits in the preceeding report, I found that these were very slightly. Comment and Summary: Although many students had discussed the problem of the myom-heart, at present, the pathogenesis of this disease is not yet established definitely. On the first report, by means of the Myom-Phosphatide Precipitation Reaction, I showed that the myom-phosphatide had the affinity to myocardium. On the second and third reports, I showed that I succeeded to produce the allergic myocarditis due to the myom-phosphatide. According to these three experiments, I believe that the disorders of the so-called myom-heart are the cardiac disturbances due to the allergic myocarditis that is caused by combined antigens of the foreign proteins, probably derived from the focal infection etc., and the myom-phosphatide which act as the determinant group in the allergic reaction.
- 社団法人日本循環器学会の論文
- 1953-04-20
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