Coenzyme Activity of NAD Analogs for 3-Isopropylmalate Dehydrogenase from Thermus thermophilus HB8
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概要
- 論文の詳細を見る
In order to elucidate the enzyme-substrate-cofactor interaction in 3-isopropylmalate dehydrogenase, the coenzyme activity of NAD analogs which have a 3-substituted pyridine ring was examined. Analogs 3-5 showed diminished k_<cat> values compared with those of NAD^+, whereas thiocar-boxamide 2 was almost as equally active as NAD^+. This suggests that the NH_2 functionality of NAD^+ is more important for the catalysis of IPMDH than a carbonyl group.
- 社団法人日本農芸化学会の論文
- 1999-09-23
著者
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CHIBA Akira
Department of Biology, School of Life Dentistry at Niigata, The Nippon Dental University
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EGUCHI Tadashi
Department of Chemistry and Materials Science, Tokyo Institute of Technology
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KAKINUMA Katsumi
Department of Chemistry, Tokyo Institute of Technology
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Chiba A
Department Of Biology Nippon Dental University School Of Dentistry At Niigata
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Oshima T
Department Of Life Science Tokyo Institute Of Technology:(present Address)faculty Of Life Science To
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Eguchi Tadashi
Dep. Of Chemistry And Materials Sci. Graduate School Of Sci. And Engineering Tokyo Inst. Of Technol.
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Eguchi T
Department Of Chemistry And Materials Science Tokyo Institute Of Technology
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Eguchi Tadashi
Department Of Chemistry And Materials Science Tokyo Institute Of Technology
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Eguchi T
Tokyo Inst. Technol. Tokyo
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Kakinuma Katsumi
Tokyo Institute of Technology, Department of Chemistry
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Kakinuma K
Tokyo Inst. Technol. Tokyo
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Kakinuma Katsumi
Department Of Chemistry And Materials Science Tokyo Institute Of Technology
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Kakinuma Katsumi
Department Of Chemistry Tokyo Inst. Of Tech.
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Oshima Tairo
School Of Life Science Tokyo University Of Pharmacy And Life Science
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Eguchi T
Kyushu Univ. Fukuoka Jpn
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Kakinuma K
Tokyo Inst. Technology Tokyo Jpn
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Chiba Akira
Department Of Biology Nippon Dental University School Of Dentistry At Niigata
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Eguchi T
Dep. Of Chemistry And Materials Sci. Graduate School Of Sci. And Engineering Tokyo Inst. Of Technol.
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Chiba Akira
Department Of Biology Nippon Dental University
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Eguchi Tadashi
Department Of Chemistry & Materials Science Tokyo Institute Of Technology
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Kakinuma Katsumi
Department of Chemistry & Materials Science, and Department of Chemistry, Tokyo Institute of Technology
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