Structure and Biosynthesis of FD-594; a New Antitumor Antibiotic
スポンサーリンク
概要
- 論文の詳細を見る
- 1998-03-25
著者
-
Eguchi Tadashi
Dep. Of Chemistry And Materials Sci. Graduate School Of Sci. And Engineering Tokyo Inst. Of Technol.
-
Eguchi T
Department Of Chemistry And Materials Science Tokyo Institute Of Technology
-
Eguchi Tadashi
Department Of Chemistry And Materials Science Tokyo Institute Of Technology
-
Eguchi T
Tokyo Inst. Technol. Tokyo
-
Kakinuma Katsumi
Tokyo Institute of Technology, Department of Chemistry
-
Mizoue K
Taisho Pharmaceutical Co. Ltd. Saitama Jpn
-
Mizoue Kazutoshi
Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd.
-
Kakinuma K
Tokyo Inst. Technol. Tokyo
-
Kakinuma Katsumi
Department Of Chemistry And Materials Science Tokyo Institute Of Technology
-
Kondo Katsuya
Department Of Chemistry Tokyo Institute Of Technology
-
QIAO Ya-fang
Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd.
-
Qiao Ya-fang
Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd.
-
Eguchi T
Dep. Of Chemistry And Materials Sci. Graduate School Of Sci. And Engineering Tokyo Inst. Of Technol.
-
Eguchi Tadashi
Department Of Chemistry & Materials Science Tokyo Institute Of Technology
-
Kakinuma Katsumi
Department of Chemistry & Materials Science, and Department of Chemistry, Tokyo Institute of Technology
関連論文
- Isolation and Structure Elucidation of Vicenistatin M, and Importance of the Vicenisamine Aminosugar for Exerting Cytotoxicity of Vicenistatin
- Structure of NG-061, a Novel Potentiator of Nerve Growth Factor (NGF) Isolated from Penicillium minioluteum F-4627
- A Novel Fungal Metabolite NG-061 Enhances and Mimics Neurotrophic Effect of Nerve Growth Factor (NGF) on Neurite Outgrowth in PC12 Cells
- Waol B, a New Trihydrofuran Derivative with Cytocidal Activity, isolated from Mlyceliophthora lutea
- A Novel Bioactive δ lactone FD-211 Taxonomy, Isolation and Characterization
- Cloning of the Pactamycin Biosynthetic Gene Cluster and Characterization of a Crucial Glycosyltransferase Prior to a Unique Cyclopentane Ring Formation
- P-188 Functional Analysis of Unique Enzymes in the Biosynthesis of Aminoglycoside Antibiotics
- Biosynthesis of 2-Deoxystreptamine-containing Antibiotics in Streptoalloteichus hindustanus JCM 3268 : Characterization of 2-Deoxy-scyllo-inosose Synthase
- Biosynthesis of 2-Deoxystreptamine by Three Crucial Enzymes in Streptomyces fradiae NBRC 12773
- Extended Sequence and Functional Analysis of the Butirosin Biosynthetic Gene Cluster in Bacillus circulans SANK 72073
- Reaction Stereochemistry of 2-Deoxy-scyllo-inosose Synthase, the Key Enzyme in the Biosynthesis of 2-Deoxystreptamine
- First Identification of Streptomyces Genes Involved in the Biosynthesis of 2-Deoxystreptamine-containing Aminoglycoside Antibiotics : Genetic and Evolutionary Analysis of L-Glutamine : 2-deoxy-scyllo-inosose Aminotransferase Genes
- Identification of L-Glutamine : 2-Deoxy-scyllo-inosose Aminotransferase Required for the Biosynthesis of Butirosin in Bacillus circulans
- Novel Substrate Specificity of Designer 3-Isopropylmalate Dehydrogenase Derived from Thermus thermophilus HB8(Biochemistry & Molecular Biology)
- Butirosin-biosynthetic Gene Cluster from Bacillus circulans
- Significance of the 20-kDa Subunit of Heterodimeric 2-Deoxy-scyllo-inosose Synthase for the Biosynthesis of Butirosin Antibiotics in Bacillus circulans(Microbiology & Fermentation Technology)
- Molecular Cloning of the Gene for the Key Carbocycle-forming Enzyme in the Biosynthesis of 2-Deoxystreptamine-containing Aminocyclitol Antibiotics and Its Comparison with Dehydroquinate Synthase
- Purification and Characterization of 2-Deoxy-scyllo-inosose Synthase Derived from Bacillus circulans. A Crucial Carbocyclization Enzyme in the Biosynthesis of 2-Deoxystreptamine-containing Aminoglycoside Antibiotics
- Enantioselective Synthesis of (2R,3S)-3-Alkylmalic Acids, Competent Substrates for 3-Isopropylmalate Dehydrogenase
- Solvent-dependent Stereochemical Anomaly in the Nucleophilic Addition of Ester-derived Enolate to Bicyclo[3,3,0]octan-2-one System of Diacetone Glucos-3-ulose
- Microbial Glycosylation of Macrolide Antibiotics by Streptomyces hygroscopicus ATCC 31080 and Distribution of a Macrolide Glycosyl Transferase in Several Streptomyces Strains
- FOREWORD
- Isolation of Enterocin SE-K4-Encoding Plasmid and a High Enterocin SE-K4 Producing Strain of Enterococcus faecalis K-4
- Isolation and Characterization of Enterocin SE-K4 Produced by Thermophilic Enterococci, Enterococcus Faecalis K-4
- Characterization of a Phage Resistance Plasmid, pLKS, of Silage-Making Lactobacillus plantarum NGRI0101
- A new method for enzymatic preparation of isopentenyladenine-type and trans-zeatin-type cytokinins with radioisotope-labeling
- The Nash Bargaining Model Used in an Optimally Designed PID Controller for Multiple Objectives
- Cytotoxic Cardenolides from Woods of Euonymus alata
- Oligomeric Stilbenes from Caragana chamlagu LAMARK Root
- Versatile Synthon for Chirally β-Deuterated L-Amino Acids and Synthesis of (3R)- and (3S)-[3-^2H_1]-L-Serine
- Involvement of Glutamate Mutase in the Biosynthesis of the Unique Starter Unit of the Macrolactam Polyketide Antibiotic Vicenistatin
- Overproduction and Substrate Specificity of 3-Isopropylmalate Dehydrogenase from Thiobacillus ferrooxidans
- Biosynthesis of (2R)-4-Amino-2-hydroxybutyric Acid, Unique and Biologically Significant Substituent in Butirosins
- 3-Isopropylidenemalic Acid:A Mechanism-based Inhibitor of 3-Isopropylmalate Dehydrogenase
- Coenzyme Activity of NAD Analogs for 3-Isopropylmalate Dehydrogenase from Thermus thermophilus HB8
- Stachybotrin C and Parvisporin, Novel Neuritogenic Compounds II. Structure Determination
- Stachybotrin C and Parvisporin, Novel Neuritogenic Compouds I. Taxonomy, Isolation, Physico-chemical and Biological Properties
- Synthesis of 2-O-Methyl Ether and 1-Carboxamide Derivatives of (2R,3S)-3-Isopropylmalic Acid and Their Interaction with Thermophilic 3-Isopropylmalate Dehydrogenase
- Synthesis of NG-061 and Its Analogs, and Their Biological Evaluation as an Enhancer of Nerve Growth Factor
- Isolation and Characterization of a New Pyrano[4', 3': 6, 7]naphtho[1, 2-b]xanthene Antibiotic FD-594
- Optical Isolator for Orthogonally Polarized Two-Frequency Laser
- Significance of the 71-Membered Macrocyclic Structure Found in Archaeal Membrane Lipids : Model Studies of the Macrocyclic Tetraether Diphospholipids by Calorimetric, ^PNMR, and Electron Microscopic Analyses
- Substrate Specificity of 2-Deoxy-scyllo-inosose Synthase, the Starter Enzyme for 2-Deoxystreptamine Biosynthesis, toward Deoxyglucose-6-phosphates and Proposed Mechanism
- Kinetic Isotope Effect and Reaction Mechanism of 2-Deoxy-scyllo-inosose Synthase Derived from Butirosin-producing Bacillus circulans
- Biosynthesis of Archaeal Membrane Lipids : Digeranylgeranylglycerophospholipid Reductase of the Thermoacidophilic Archaeon Thermoplasma acidophilum
- A Novel Neuritogenic Compound, NGA0187
- Roles of a 20kDa Protein Associated with a Carbocycle-Forming Enzyme Involved in Aminoglycoside Biosynthesis in Primary and Secondary Metabolism
- Production and Structural Analysis of PP-V, a Homologue of Monascorubramine, Produced by a New Isolate of Penicillium sp.
- Structure and Biosynthesis of FD-594; a New Antitumor Antibiotic
- PC83 SARKOMYCIN ANALOGUES AS HIGHLY ACTIVE ANTIMUTAGENS AGAINST UV-INDUCED MUTATION IN Escherichia coli
- Possible Interaction of Thiol Groups of Proteins with Antimutagens Containing a Conjugated Carbonyl Structure(Organic Chemistry)
- Structure Revision of FD-891, a 16-Membered Macrolide Antibiotic
- P-51 Genome-Inspired Search for New Polyketide Antibiotic Halstoctacosanolides from Streptomyces halstedii HC34
- The Complete Biosynthetic Gene Cluster of the 28-Membered Polyketide Macrolactones, Halstoctacosanolides, from Streptomyces halstedii HC34
- Enantioselective and Convergent Synthesis of the 20-Membered Lactam Aglycon of Vicenistatin Antitumor Antibiotic
- Functional Analysis of Type 1 Isopentenyl Diphosphate Isomerase from Halobacterium sp. NRC-1
- MYOSIN ISOFORMS AND THEIR LOCALIZATION IN CYTOSOL AND MEMBRANE FRACTIONS OF PERITONEAL NEUTROPHILS FROM GUINEA PIG.(Biochemistry)(Proceedings of the Sixty-Second Annual Meeting of the Zoological Society of Japan)
- Electrophilic Reaction on Plinol C and Syntheses of Functionalized 2-Oxabicyclo[2,2,1]heptane Derivatives(Organic Chemistry)
- A New Isopatulin Derivative Pintulin Produced by Penicillium Vulpinum F-4148 Taxonomy, Isolation, Physico-chemical Properties, Structure and Biological Properties
- PA85 FD-017 AND FD-018, NEW BIOACTIVE COMPOUNDS RELATED TO OVALICIN
- Highly Thermostable Liposome from 72-Membered Macrocyclic Tetraether Lipid: Importance of 72-Membered Lipid for Archaea to Thrive under Hyperthermal Environments
- 36-Membered Macrocyclic Diether Lipid is Advantageous for Archaea to Thrive under the Extreme Thermal Environments
- Specific Deuterium Labeling of Archaeal 36-Membered Macrocyclic Diether Lipid
- Tightly Packed Membranes Composed of 36-Membered Macrocyclic Diether Phosholipid Found in Archaea Growing under Deep-sea Hydrothermal Vents
- Structural Diversity of the Membrane Core Lipids of Extreme Halophiles
- Synthetic Studies of Archaeal Macrocyclic Tetraether Lipids: Practical Synthesis of 72-Membered Tetraether Model Compounds
- Short Synthesis of (±)-Chokol G, the Simplest Congenor of the Chokol Group of Fungitoxic Sesquiterpenoids(Organic Chemistry)
- Confirmation of the Absolute Stereo-chemistry of sn-2,3-Di-O-phytanyl Glycerol, the Unit Lipid of the Cell Membrane of Halophilic Archaebacteria Halobacterium halobium(Organic Chemistry)
- Mevalonolactone-d_9 ; A Versatile Tool for Biosynthetic Study of Isoprenoids. Synthesis and Its Application
- Structure of Thermus thermophilus homoisocitrate dehydrogenase in complex with a designed inhibitor
- The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells
- Cloning of the biosynthetic gene cluster for naphthoxanthene antibiotic FD-594 from Streptomyces sp. TA-0256
- Biosynthetic genes for aminoglycoside antibiotics
- Enzymatic preparation of neomycin C from ribostamycin
- Enzymatic activity of a glycosyltransferase KanM2 encoded in the kanamycin biosynthetic gene cluster
- Differences in the Roles of a Glutamine Amidotransferase Subunit of Pyridoxal 5'-Phosphate Synthase between Bacillus circulans and Bacillus subtilis
- Characterization of Polyphosphate Glucokinase SCO5059 from Streptomyces coelicolor A3(2)
- Differences in the Roles of a Glutamine Amidotransferase Subunit of Pyridoxal 5'-Phosphate Synthase between Bacillus circulans and Bacillus subtilis