Enantioselective Synthesis of (2R,3S)-3-Alkylmalic Acids, Competent Substrates for 3-Isopropylmalate Dehydrogenase
スポンサーリンク
概要
- 論文の詳細を見る
A series of (2R,3S)-3-alkylmalic acids was enantioselectively synthesized, in conjunction with biochemical studies on the thermostable isopropylmalate dehydrogenase derived from Thermus thermophilus, by the chirality transcription approach, using a conceptually recyclable carbohydrate template. The dianion [2,3]-Wittig rearrangement of alkylated allyloxyacetic acids prepared from alkylallyl tertiary-carbinols was effective in both reactivity and stereoselectivity to afford the desired diastereomers in a high yield. The derived γ,δ-unsaturated α-hydroxycarboxylic acids were oxidatively transformed into the desired (2R,3S)-3-alkylmalic acid derivatives.
- 社団法人日本農芸化学会の論文
- 1993-11-23
著者
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Oshima Tairo
Department of Molecular Biology, School of Life Science, Tokyo University of Pharmacy and Life Scien
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KAKINUMA Katsumi
Department of Chemistry, Tokyo Institute of Technology
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Oshima T
Department Of Life Science Tokyo Institute Of Technology:(present Address)faculty Of Life Science To
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Kakinuma Katsumi
Tokyo Institute of Technology, Department of Chemistry
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Li Hui-ying
Department Of Chemistry Tokyo Institute Of Technology
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Terasawa Hiroaki
Department of Chemistry, Tokyo Institute of Technology
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Miyazaki Kentaro
Department of Life Science, Tokyo Institute of Technology
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Kakinuma K
Tokyo Inst. Technol. Tokyo
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Kakinuma Katsumi
Department Of Chemistry And Materials Science Tokyo Institute Of Technology
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Oshima Tairo
Department Of Life Science Faculty Of Biocscience And Bioctechnology Tokyo Institute Of Technology
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Miyazaki Kentaro
Department Of Life Science Tokyo Institute Of Technology
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Miyazaki Katsunori
Chemistry Laboratories Nippon Shinyaku Co. Ltd.
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Terasawa Hiroaki
Department Of Chemistry Tokyo Institute Of Technology
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Kakinuma Katsumi
Department of Chemistry & Materials Science, and Department of Chemistry, Tokyo Institute of Technology
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