Immunopotentiating Activity of Nigerooligosaccharides for the T Helper 1-Like Immune Response in Mice
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概要
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The immunopotentiating activity of nigerooligosaccharides (NOS), a mixture of nigerose, nigerosyl glucose and nigerosyl maltose, was studied in vitro and in vivo in mice. Mitogen-induced proliferation of splenocytes from normal mice was augmented in a dose-dependent manner by nigerose of NOS. NOS enhanced interleukin 12 (IL-12) and interferon-γ (IFN-γ) production by normal splenocytes in the presence of the potent IL-12 inducer, heat-killed Lactobacillus plantarum L-137,in vitro. Consistent with the in vitro finding, L. plantarum L-137-induced IL-12 production and IL-2-induced IFN-γ production were augmented in mice fed with a 14.6% NOS diet for 2 weeks compared with mice fed with a control diet. Notably, mice fed with the NOS diet showed significantly longer survival time than the control mice after the induction of an endogenous infection by administering 5-fluorouracil in a lethal dose. Taken together, these results suggest that NOS may exert immunopotentiating activity through the activation of an IL-12-dependent T helper 1-like immune response.
- 社団法人日本農芸化学会の論文
- 1999-02-23
著者
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Yoshikai Y
Nagoya Univ. School Of Medicine Aichi Jpn
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YOSHIKAI Yasunobu
Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control
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MUROYAMA Koutarou
Research and Development Section, Takeda Food Products Ltd.
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MUROSAKI Shinji
Research and Development Section, Takeda Food Products Ltd.
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YAMAMOTO Yoshihiro
Research and Development Section, Takeda Food Products Ltd.
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KUSAKA Hiroaki
Research & Development Section, Takeda Food Products Ltd.
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LIU Tiei
Laboratory of Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University
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Liu Tiei
Laboratory Of Germfree Life Research Institute For Disease Mechanism And Control Nagoya University S
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Kusaka Hiroaki
Research & Development Section Takeda Food Products Ltd.
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Murosaki S
Takeda Food Products Ltd. Itami Jpn
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Murosaki Shinji
Research And Development Section Takeda Food Products Ltd.
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Yamamoto Y
Division Of Integrated Life Science Graduate School Of Biostudies Kyoto University
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Yamamoto Y
Faculty Of Bio-resource Sciences Akita Prefectural University
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Yamamoto Yoshihiro
Research And Development Department Takeda Food Products Ltd.
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Yoshikai Yasunobu
Laboratory Of Germfree Life Research Institute For Disease Mechanism And Control Nagoya University S
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Muroyama K
Takeda Food Products Ltd. Itami Jpn
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