Permeation of Hesperidin Glycosides Across Caco-2 Cell Monolayers Via the Paracellular Pathway
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概要
- 論文の詳細を見る
The intestinal permeability to hesperidin glycosides was investigated by using a cultured monolayer of Caco-2 as a model for the small intestinal epithelium. Hesperidin glycosides were added to the apical side of the monolayer, and the substances that permeated to the basolateral side were determined by HPLC. Whereas hesperidin did not permeate across the Caco-2 monolayer, probably owing to its low solubility, the hesperidin glycosides did permeate. The transepithelial transport of hesperidin glycosides occurred in time-and dose-dependent manners. The transport was observed to be energy-independent, and was inversely correlated with the transepithelial electrical resistance (TEER) of the monolayer. These results suggest that hesperidin glycosides permeate across the Caco-2 cell monolayer via the paracellular pathway.
- 社団法人日本農芸化学会の論文
- 1999-12-23
著者
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Kometani Takashi
Biochemical Research Laboratory Ezaki Glico Co. Ltd.
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Okada Shigetaka
Biochemical Research Laboratory Ezaki Glico Co. Ltd.
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KIM Minji
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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SHIMUZU Makoto
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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Kim Minji
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Shimuzu Makoto
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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