Sequence Analysis of Functional Regions of Homoserine Dehydrogenase Genes from L-Lysine and L-Threonine-producing Mutants of Brevibacterium lactofermentum

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概要

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• The homoserine dehydrogenase (HD) genes from Brevibacterium lactofermentum lysine- and threonine-producing mutants were cloned, using the polymerase chain reaction, and sequenced. We found the amino acid substitutions, Val104Ile in the lysine-producing mutants in which HD may cause leaky mutation and Ser393Phe in the threonine-producing mutant with feedback-insensitive HD.

• 社団法人日本農芸化学会の論文
• 1997-10-23

著者

• MATSUI HIROSHI

  Central Research Laboratories, Ajinomoto Co., Inc.,

• Nakamori Shigeru

  Central Research Laboratories Ajinomoto Co. Inc.

• Nakamori Shigeru

  Central Research Laboratories Ajinomoto Co. Inc.:(present Address)department Of Bioscience Fukui Pre

• TAKAGI Hiroshi

  Central Research Laboratories of Ajinomoto Co., Inc.

• SUGIMOTO Masakazu

  Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Sugimoto Masakazu

  Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• SUGIMOTO Masakazu

  Central Research Laboratories, Ajinomoto Co., Inc.

• TANAKA Akiko

  Central Research Laboratories, Ajinomoto Co., Inc.

• SUZUKI Tomoko

  Central Research Laboratories, Ajinomoto Co., Inc.

• Matsui Hiroshi

  Central Research Laboratories Ajinomoto Co. Inc.

• Takagi Hiroshi

  Central Research Laboratories Ajinomoto Co. Inc.:(present Address)department Of Bioscience Fukui Pre

• Takagi Hiroshi

  Central Research Laboratories Ajinomoto Co. Inc.

• Suzuki Tomoko

  Central Research Laboratories Ajinomoto Co. Inc.

• Tanaka Akiko

  Central Research Laboratories Ajinomoto Co. Inc.

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