Changes in the Number and Apoptosis of Epithelial Cells in the Colorectum of Wheat Bran-fed Rats Soon after Administering 1, 2-Dimethylhydrazine
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概要
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We investigated the effect of dietary wheat bran (Wb) on colonic tumorigenesis soon after a single administration of 1, 2-dimethylhydrazine (DMH). Rats that had been fed on either a fiber-free diet or a 20% Wb diet were injected with 1, 2-dimethylhydrazine (20 mg/kg body weight). At 6h, 12h, 1d, 3d, or 7d after the injection, the colorectum was excised for histological analyses. The number of crypt cells more rapidly recovered in the 20% Wb group than in the fiber-free group after its temporary reduction by injection of DMH. At 6 h after the DMH treatment, the apoptotic cells were signiticantly greater in number in the fiber-free group than in the 20% Wb group. In contrast, those in distal colon were significantly fewer in the fiber-free group than in the 20% Wb group at 7d after the treatment. These results suggest that the ingestion of Wb affected the turnover of colonic epithelial cells and would thereby bring about a protective effect against DMH-induced tumorigenesis.
- 社団法人日本農芸化学会の論文
- 1997-08-23
著者
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Sonoyama Kei
Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University
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Sonoyama Kei
Department Of Bioscience And Chemistry Faculty Of Agriculture Hokkaido University
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KASAI Takanori
Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University
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Kasai Takanori
Department Of Agricultura Chemistry Faculty Of Agriculture Hokkaido University
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ISHIZUKA Satoshi
Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University
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Ishizuka Satoshi
Department Of Bioscience And Chemistry Faculty Of Agriculture Hokkaido University
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