Simultaneous and High Fermentative Production of L-Lysine and L-Glutamic Acid Using a Strain of Brevibacterium lactofermentum
スポンサーリンク
概要
- 論文の詳細を見る
A novel fermentation process for simultaneous and high production of L-lysine and L-glutamic acid was established. This process was characterized by cultivating an L-lysine-producing strain with the cultivating methods for the production of L-glutamic acid, that is, cultivations with the addition of surface-active agents or penicillin. By these methods, without the addition of ammonium sulfate to culture medium, simultaneous and high production of L-lysine and L-glutamic acid with 1.3-1.4 fold higher productivity than that of the control was achieved. Various expected merits of this process from the viewpoint of industrial production of amino acids are discussed. It was suggested from the analysis of this newly-found fermentation process that the accumulation of L-glutamic acid could not be explained only the usual "leakage model" through the injury of cell membrane, but it would be necessary to consider the alterations in L-glutamic acid biosynthetic system.
- 社団法人日本農芸化学会の論文
- 1995-01-23
著者
-
YOSHIHARA Yasuhiko
Technology & Engineering Laboratories of Ajinomoto Co., Inc.
-
KAWAHARA Yoshio
Fermentation and Biotechnology Laboratories, Ajinomoto Co., Inc.
-
Nakamori Shigeru
Department Of Bioscience Faculty Of Bioscience Fukui Prefectural University
-
Kawahara Y
Fermentation And Biotechnology Laboratories Ajinomoto Co. Inc.
-
Kawahara Yoshio
Technology And Engineering Center Of Ajinomoto Co. Inc.
-
Miwa H
Ibaraki Univ. Ibaraki Jpn
-
Shiratsuchi Mototsugu
Technology and Engineering Laboratories of Ajinomoto Co., Inc.
-
Kuronuma Hideo
Technology and Engineering Laboratories of Ajinomoto Co., Inc.
-
Miwa Harufumi
Technology and Engineering Laboratories of Ajinomoto Co., Inc.
-
Kuronuma Hideo
Technology And Engineering Laboratories Of Ajinomoto Co. Inc.
-
Shiratsuchi Mototsugu
Technology And Engineering Laboratories Of Ajinomoto Co. Inc.
-
Yoshihara Yasuhiko
Technology And Engineering Laboratories Of Ajinomoto Co. Inc.
関連論文
- Old Yellow Enzyme from Candida macedoniensis Catalyzes the Stereospecific Reduction of the C=C Bond of Ketoisophorone(Microbiology & Fermentation Technology)
- Occurrence of Multiple Ethyl 4-Chloro-3-Oxobutanoate-Reducing Enzymes in Candida magnoliae
- Cloning, Sequence Analysis, and Expression in Escherichia coli of the Gene Encoding Monovalent Cation-activated Levodione Reductase from Corynebacterium aquaticum M-13
- Improved L-Leucine Production by an α-Aminobutyric Acid Resistant Mutant of Brevibacterium lactofermentum
- Glutamate Overproduction in Corynebacterium glutamicum Triggered by a Decrease in the Level of a Complex Comprising DtsR and a Biotin-containing Subunit
- Partial Purification of Phytase from a Soil Isolate Bacterium, Klebsiella oxytoca MO-3
- The Production of Recombinant APRP, an Alkaline Protease Derived from Bacillus pumilus TYO-67, by In Vitro Refolding of Pro-enzyme Fixed on a Solid Surface
- Improved Autoprocessing Efficiency of Mutant Subtilisins E with Altered Specificity by Engineering of the Pro-Region^1
- Cryoprotective Effect of the Serine-Rich Repetitive Sequence in Silk Protein Sericin^1
- The Energetic Conversion Competence of Escherichia coli during Aerobic Respiration Studied by ^P NMR Using a Circulating Fermentation System
- Purification and Characterization of 0-Acetylserine Sulfhydrylase of Corynebacterium glutamicum
- Cloning and Overexpression of the Exiguobacterium sp. F42 Gene Encoding a New Short Chain Dehydrogenase, Which Catalyzes the Stereoselective Reduction of Ethyl 3-Oxo-3-(2-thienyl)propanoate to Ethyl (S)-3-Hydroxy-3-(2-thienyl)propanoate
- Enhanced Thermostability of the Single-Cys Mutant Subtilisin E under Oxidizing Conditions^1
- 2S107 Metabolism and regulation of L-cysteine in Brevibacterium flavum (Corynebacterium glutamicum)
- Proline in the Osmoregulation of Brevibacterium lactofermentum(Biological Chemistry)
- Characterization of Novel Acetyltransferases Found in Budding and Fission Yeasts That Detoxify a Proline Analogue, Azetidine-2-Carboxylic Acid
- Development of Gene Delivery Systems for the ε-Poly-L-Lysine Producer, Streptomyces albulus(Genetics, Molecular Biology, and Gene Engineering)
- Overexpression and Characterization of an Aminoglycoside 6'-N-Acetyltransferase with Broad Specificity from an ε-Poly-L-lysine Producer, Streptomyces albulus IFO14147
- Cloning and Analysis of the β-Lactamase Gene from ε-Poly-L-lysine-Producing Actinomycete Streptomyces albulus IFO14147
- Effect of Proline and Arginine Metabolism on Freezing Stress of Saccharomyces cerevisiae(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Effect of Gene Disruption of Succinate Dehydrogenase on Succinate Production in a Sake Yeast Strain
- Efficient Selection for Thermostable Protease in Themus thermophilus
- Engineering Subtilisin E for Enhanced Stability and Activity in Polar Organic Solvents
- Isolation and Sequence Analysis of Plasmid pNO33 in the ε-Poly-_L-Lysine-Producing Actinomycete Streptomyces albulus IFO1417
- Relationship between the Glutamate Production and the Activity of 2-Oxoglutarate Dehydrogenase in Brevibacterium lactofermentum
- Simultaneous and High Fermentative Production of L-Lysine and L-Glutamic Acid Using a Strain of Brevibacterium lactofermentum
- Molecular Cloning of a Novel Gene, dtsR, Which Rescues the Detergent Sensitivity of a Mutant Derived from Brevibacterium lactofermentum
- Improved Production and Recovery of Alkaline Elastase from Alkalophilic Bacillus Strain by a Change of Medium Composition