IMPROVEMENT OF PACING INDUCED REGIONAL MYOCARDIAL ISCHEMIA BY SOLCOSERYL IN CONSCIOUS DOGS WITH CORONARY STENOSIS
スポンサーリンク
概要
- 論文の詳細を見る
The effects of Solcoseryl on regional myocardial function were studied in 5 conscious dogs with partial coronary constriction, in which temporary ischemia was induced by rapid cardiac pacing. During the coronary artery constriction, the percent shortening of the ischemic segment decreased by 9%. When the heart rate was increased by pacing, the percent shortening of the ischemic segments was further reduced by 57%. On cessation of cardiac pacing, the early potentiation of dP/dt and of control segment shortening became evident and was followed by exponential decay in the subsequent several beats. In the ischemic segment, the percent shortening was significantly improved in the first post-pacing beat but was more severely depressed at five seconds. Thirty minutes after administration of Solcoseryl, the cardiac pacing was repeated in the same manner but the pacing-induced hypokinesia of the ischemic segment were less marked, the percent shortening being at an average of 9.1% during control pacing and 12.7% during the second pacing after Solcoseryl (p<0.05). Postpacing deterioration of the ischemic segment shortening was also significantly improved from 9.8 to 11.8% at 5 seconds (p<0.05). These findings indicate that Solcoseryl exerts protective effects on the ischemic myocardium by promoting a rapid recovery from ischemia, probably due to the improvement of oxygen utility through activated cellular respiration.
- 社団法人日本循環器学会の論文
- 1984-02-20
著者
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Takahashi Masaaki
The Third Division Department Of Internal Medicine Kyoto University
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Sasayama Shigetake
浜松労災病院
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Tanaka Masahiro
Rakuwakai Otowa Hospital
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Kawai Chuichi
The Third Division Department Of Internal Medicine. Faculty Of Medicine Kyoto University
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SASAYAMA SHIGETAKE
The Third Division,Department of Internal Medicine,Kyoto University Hospital
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Sasayama Shigetake
The Third Division Of Medicine Kyoto University
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Shimada Toshio
The Third Division Department Of Internal Medicine Kyoto University
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Sawada Shigeo
Virus Center National Kyoto Hospital
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Sasayama Shigetake
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Sasayama Shigetake
The Third Division Department Of Internal Medicine And Central Clinical Laboratory Kyoto University
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Sasayama Shigetake
Division Of Medicine Hamamatsu Rosai Hospital Shizuoka
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Kawai Chuichi
The Third Department Of Internal Medicine Faculty Of Medicine Kyoto University
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OSAKADA GENTA
The Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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Sasayama Shigetake
Department Of Cardiology Doshisha University
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Osakada Genta
Central Clinical Laboratory Kyoto University Hospital
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Sasayama Shigetake
The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Osakada Genta
The 3rd Dept. Of Internal Medicine Kyoto Univ. Hospital
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Sasayama Shigetake
Third Division Department Of Internal Medicine Kyoto University
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Sasayama Shigetake
Second Division Internal Medicine Toyama Medical And Pharmaceutical School
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Takahashi Masaaki
The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Sasayama Shigetake
Thesecond Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Takashima Masayuki
Cardiovascular Center Osaka Red Cross Hospital
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