Effects of Nocturnal Oxygen Therapy on Outcome Measures in Patients With Chronic Heart Failure and Cheyne-Stokes Respiration

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• Background The effects of nasal oxygen (O_2) supply at night using conventional home oxygen therapy (HOT) equipment on quality of life (QOL) and sleep-disordered breathing (SDB) were evaluated in patients with congestive heart failure (CHF). Nasal nocturnal O_2 therapy not only stabilizes SDB but also reduces sympathetic activity, and improves exercise capacity in patients with CHF. However, the effects of oxygen on the cardiac function and QOL of heart failure patients have not been fully elucidated. Methods and Results Fifty-six patients with CHF (New York Heart Association class II-III, left ventricular ejection fraction (LVEF) ≤45%) and central sleep apnea (CSA) with Cheyne-Stokes respiration (CSR) were randomly assigned to receive either nocturnal O_2 (HOT group, n=25) or usual breathing (control group, n=31) for 12 weeks. Respiration, airflow and arterial oxygen levels were monitored with determination of apnea/hypopnea index (AHI) and oxygen desaturation index (ODI) during sleep. LV function was determined by radionuclide angiography or echocardiography. QOL was assessed by the Specific Activity Scale questionnaire. In the HOT group, nocturnal O_2 resulted in significant improvements in AHI (21.0±10.8 to 10.0±11.6 events/h, mean±SD, p<0.001), ODI (19.5±9.8 to 5.9±8.7 dips/h, p<0.001) and Specific Activity scale (4.0±1.2 to 5.0±1.5 Mets, p<0.001). LVEF also increased from baseline to the end of the study (34.7±10.4 to 38.2±13.6%, p=0.022). Conclusions In patients with stable CHF and CSR, HOT at night improves SDB, LV function and QOL, and thus is a valuable nonpharmacological option for the treatment of patients with CHF and CSR-CSA.

• 社団法人日本循環器学会の論文
• 2005-12-20

著者

• Asanoi Hidetsugu

  Imizu City Hospital

• IMAIZUMI Tsutomu

  Kurume University

• Sasayama S

  Department Of Life And Medical Science Doshisha University Kyotanabe & Daijukai Hospital

• Sasayama Shigetake

  浜松労災病院

• Sudo Y

  Suzuki Clinic

• Sasayama Shigetake

  The Department Of Cardiology Hyogo Prefectural Amagasaki Hospital

• Sasayama Shigetake

  Department Of Life And Medical Science Doshisha University Kyotanabe & Daijukai Hospital

• Saijyo Sayaka

  Department Of Cardiology Hyogo Prefectural Amagasaki Hospital

• Ueshima Kenji

  Ebm Research Center Graduate School Of Medicine Kyoto University

• IMAIZUMI Tutomu

  VALISH Study Group

• Sawada Shigeo

  Department Of Cardiology Doshisha University

• Sasayama Shigetake

  The Third Division Of Medicine Kyoto University

• Sasayama Shigetake

  Hamamatsu Rosai Hospital

• Izumi Toru

  Hamamatsu Rosai Hospital

• Seino Yoshihiko

  Hamamatsu Rosai Hospital

• Ueshima Kenji

  Hamamatsu Rosai Hospital

• Asanoi Hidetsugu

  Hamamatsu Rosai Hospital

• Izumi Taketeru

  Department Of Cardio-angiology Kitasato University School Of Medcine

• Imaizumi Tsutomu

  Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit

• Sasayama Shigetake

  Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University

• Sasayama Shigetake

  Division Of Medicine Hamamatsu Rosai Hospital Shizuoka

• Saijyo Sayaka

  The Department Of Cardiology Hyogo Prefectural Amagasaki Hospital

• Imaizumi Tsutomu

  The Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Unive

• Sasayama Shigetake

  Third Division Department Of Internal Medicine Kyoto University

• Sasayama Shigetake

  Second Division Internal Medicine Toyama Medical And Pharmaceutical School

• Sasayama Shigetake

  Department Of Cardiovascular Medicine Graduate School Of Medicine

• Izumi Toru

  Department Of Cardiovascular Medicine Kitasato University School Of Medicine

• Saijo Sayaka

  Department Of Cardiology Hyogo Prefectural Amagasaki Hospital

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