Local Implantation of Autologous Bone Marrow Cells for Therapeutic Angiogenesis in Patients With Ischemic Heart Disease : Clinical Trial and Preliminary Results

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概要

• 論文の詳細を見る

• A new therapy for severe ischemic heart disease has been developed ; therapeutic angiogenesis induced by the local implantation of autologous bone marrow cells(BMC). After confirming that no detrimental changes were induced by this treatment in a canine heart model, a clinical trial was commenced in 1999. Thus far, 5 patients have been given this new treatment concomitant with coronary artery bypass grafting and all have been followed up for at least 1 year. Autologous BMC were implanted into the ungraftable area and postoperative cardiac scintigraphy showed specific improvement in coronary perfusion in 3 of the 5 patients. Postoperative chest radiography, electrocardiography, echocardiography and blood tests did not reveal any detrimental changes. In conclusion, this new therapy appears to be safe and could provide a treatment option for patients with otherwise untreatable ischemic heart disease.

• 社団法人日本循環器学会の論文
• 2001-08-20

著者

• Miura Toshiro

  Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine

• Matsuzaki Masunori

  Second Department of Internal Medicine, Yamaguchi University, School of Medicine

• Li Tao-sheng

  Department Of Surgery And Clinical Science Yamaguchi University Graduate School Of Medicine

• Mikamo Akihito

  Department Of Cardiac Surgery And Clinical Sciences Yamaguchi University Graduate School Of Medicine

• Harada Masahiko

  Second Department of Internal Medicine, Yamaguchi University School of Medicine

• Miura Toshiro

  Second Department Of Internal Medicine Yamaguchi University School Of Mediciney

• Hamano Kimikazu

  First Department of Surgery, Yamaguchi University School of Mediciney

• Nishida Masahiko

  First Department of Surgery, Yamaguchi University School of Mediciney

• Hirata Ken

  First Department of Surgery, Yamaguchi University School of Mediciney

• Mikamo Akihito

  First Department of Surgery, Yamaguchi University School of Mediciney

• Li Tao-Sheng

  First Department of Surgery, Yamaguchi University School of Mediciney

• Esato Kensuke

  First Department of Surgery, Yamaguchi University School of Mediciney

• Hirata Ken

  First Department Of Surgery Yamaguchi University School Of Mediciney

• Li Tao-sheng

  First Department Of Surgery Yamaguchi University School Of Medicine

• Esato K

  Department Of Surgery Yamaguchi University School Of Medicine

• Esato Kensuke

  First Department Of Surgery.yamaguchi University School Of Medicine

• Esato Kensuke

  First Department Of Surgery Yamaguchi University School Of Medicine

• Hamano Kimikazu

  Department Of Cardiac Surgery And Clinical Sciences Yamaguchi University Graduate School Of Medicine

• Nishida Masahiko

  First Department Of Surgery Yamaguchi University School Of Mediciney

• Matsuzaki Masunori

  Second Department Of Internal Medicine Yamaguchi University School Of Medicine

• Harada Masahiko

  Second Department Of Internal Medicine Yamaguchi University School Of Mediciney

• Esato Kensuke

  First Department Of Surgery Yamaguchi University School Of Medicine.

• Hamano Kimikazu

  First Department Of Surgery Yamaguchi University School Of Medicine

• Esato Kensuke

  First Department Of Surgery

• Hamano Kimikazu

  First Department Of Surgery Yamaguchi University Hospital

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