Carvedilol Inhibits Mitochondrial Oxygen Consumption and Superoxide Production During Calcium Overload in Isolated Heart Mitochondria
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概要
- 論文の詳細を見る
Background The COMET study suggested the better effect of carvedilol to metoprolol in treating heart failure. However, its underlying mechanisms of action remain unclear. As a result, evaluation of the distinct effects of both drugs on the mitochondrial function and reactive oxygen species (ROS) production during Ca^<2+> overload was investigated. Methods and Results The mitochondrial oxygen consumption (mVO_2) and the mitochondrial ROS production in isolated rat heart mitochondria was measured. Ca^<2+> overload from 10 to 100μmol/L augmented mVO_2 was from 527±139 to 671±138 nmol/mg (p<0.05), and this was then completely suppressed by carvedilol (1μmol/L), but not by metoprolol (100μmol/L). Ca^<2+> overload augmented the ROS production upon complex I injury (9.7±1.2 to 11.4±1.4 nmol/mg, p<0.05). Carvedilol dose-dependently suppressed this ROS production, whereas metoprolol did not. Conclusions Carvedilol, but not metoprolol, was thus found to inhibit the calcium-dependent augmentation of mVO_2 and ROS production upon complex I injury. This new effect of carvedilol might partly explain the beneficial effect of carvedilol for the treatment of heart failure.
- 社団法人日本循環器学会の論文
- 2006-02-20
著者
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Miura Toshiro
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Fukagawa Yasuhiro
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Kawamura Shuji
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Kametani Ryosuke
The Department of Cardiovascular Medicine, Yamaguchi University Graduate School of Medicine
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Miura Toshiro
The Department of Cardiovascular Medicine, Yamaguchi University Graduate School of Medicine
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Harada Nozomu
The Department of Cardiovascular Medicine, Yamaguchi University Graduate School of Medicine
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Shibuya Masaki
The Department of Cardiovascular Medicine, Yamaguchi University Graduate School of Medicine
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Wang Ruijuan
The Department of Cardiovascular Medicine, Yamaguchi University Graduate School of Medicine
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Tan Hong
The Department of Cardiovascular Medicine, Yamaguchi University Graduate School of Medicine
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Fukagawa Yasuhiro
The Department of Cardiovascular Medicine, Yamaguchi University Graduate School of Medicine
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Kawamura Shuji
The Department of Cardiovascular Medicine, Yamaguchi University Graduate School of Medicine
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Matsuzaki Masunori
The Department of Cardiovascular Medicine, Yamaguchi University Graduate School of Medicine
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Tan Hong
The Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
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Shibuya Masaki
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Kametani Ryosuke
The Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
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Wang Ruijuan
The Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
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Fukagawa Yasuhiro
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Kawamura Shuji
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Kawahara Shinji
Devision Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University School Of Me
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Harada Nozomu
The Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
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Miura Toshiro
Second Department Of Internal Medicine Yamaguchi University School Of Mediciney
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Matsui Toshihiro
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Kawahara Shinji
Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
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Miura Toshiro
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Kametani Ryousuke
Division Of Cardiovascular Medicine Department Of Medical Bioregulation Yamaguchi University School
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Matsui Toshihiro
Department Of Rheumatology National Hospital Organization Sagamihara Hospital
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Miyazaki Tsuyoshi
Department Of Rheumatology Sagamihara National Hospital National Hospital Organization (nho)
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Miura T.
Second Department Of Internal Medicine Yamaguchi University School Of Medicine
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Matsuzaki Masunori
The Depart. Of Int. Med. Yamaguchi Univers. School Of Med.
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