Transient Increase of Cytokines in the Acute Ischemic Tissue is Beneficial to Cell-Based Therapeutic Angiogenesis
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概要
- 論文の詳細を見る
Background Implantation of bone marrow cells (BMCs) is a treatment of ischemic disease. It is well known that many inflammatory cytokines are released in ischemic tissue, especially in the acute phase, so in the present study it was investigated if the transient increase of cytokines in the acute ischemic tissue influences cell-based therapeutic angiogenesis. Methods and Results Ischemic limb models were created in C57BL/6 mice as 24h (acute) or 2 weeks (chronic) after ischemia. BMCs were cultured with total tissue protein, which was extracted from the acute and chronic ischemic muscles. The survival, adhesion, and migration of BMCs were significantly better after culture with 1mg/ml total tissue protein extracted from the acute ischemic limbs than from the chronic ischemic limbs (p<0.001). For the in-vivo study, 8×10^6 BMCs, collected from green fluorescent protein(GFP) transgenic mice, were implanted into the acute or chronic ischemic limbs of the mice. The survival of implanted cells and blood flow were significantly better when BMCs were implanted into the acute ischemic limbs than into the chronic ischemic limbs (p<0.001). Conclusions A transient increase of cytokines in the acute ischemic tissue is beneficial for cell-based therapeutic angiogenesis.
- 社団法人日本循環器学会の論文
- 2008-11-20
著者
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Li Tao-sheng
Department Of Surgery And Clinical Science Yamaguchi University Graduate School Of Medicine
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Furutani Akira
Department Of Cardiac Surgery And Clinical Sciences Yamaguchi University Graduate School Of Medicine
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Furutani Akira
Department Of Surgery And Clinical Science Yamaguchi University Graduate School Of Medicine
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Hamano Kimikazu
Department Of Cardiac Surgery And Clinical Sciences Yamaguchi University Graduate School Of Medicine
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Li Tao-sheng
Department Of Surgery And Clinical Science Division Of Pediatric Surgery Yamaguchi University Gradua
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Kubo Masayuki
Department Of Surgery And Clinical Science Yamaguchi University Graduate School Of Medicine
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Qin Shu-Lan
Department of Surgery and Clinical Science, Yamaguchi University, Graduate School of Medicine
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Ohshima Mako
Department of Surgery and Clinical Science, Yamaguchi University, Graduate School of Medicine
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Qin Shu-lan
Department Of Surgery And Clinical Science Yamaguchi University Graduate School Of Medicine
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Ohshima Mako
Department Of Surgery And Clinical Science Yamaguchi University Graduate School Of Medicine
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