Regression of abdominal aortic aneurysms by pharmacological inhibition of c-Jun N-terminal kinase
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概要
- 論文の詳細を見る
Abdominal aortic aneurysm (AAA) is characterized by chronic inflammation and proteolytic degradation of the extracellular matrix (ECM). Recently, we identified c-Jun N-terminal kinase (JNK) as a key molecule in the pathogenesis of AAA. Human AAA tissue showed a high level of active JNK. In in vitro studies, JNK not only activated the expression of ECM-degrading enzymes, but also suppressed the expression of enzymes for ECM biosynthesis. Finally, pharmacological inhibition of JNK not only prevented the development of AAA but also caused the regression of established AAA in mouse models. Thus, pharmacological inhibition of JNK may provide a novel therapeutic option for treatment of human AAA.
- Yamaguchi University School of Medicineの論文
著者
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Ikeda Yasuhiro
山口大学 医学系研究科
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Aoki Hiroki
Department of Molecular Cardiovascular Biology, Yamaguchi University School of Medicine
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Yoshimura Koichi
Department of Molecular Cardiovascular Biology, Yamaguchi University School of Medicine
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Ikeda Yasuhiro
山口大学 医学系研究科器官病態内科学
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Aoki Hiroki
Cardiovascular Research Institute Kurume University
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Furutani Akira
Department Of Cardiac Surgery And Clinical Sciences Yamaguchi University Graduate School Of Medicine
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Furutani Akira
Department Of Surgery And Clinical Science Yamaguchi University Graduate School Of Medicine
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Aoki Hiroki
Department Of Molecular Cardiovascular Biology
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Yoshimura Koichi
Department Of Molecular Cardiovascular Biology Yamaguchi University School Of Medicine
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Furutani Akira
First Department Of Surgery Yamaguchi University School Of Medicine
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Hamano Kimikazu
Department Of Cardiac Surgery And Clinical Sciences Yamaguchi University Graduate School Of Medicine
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Ikeda Yasuhiro
Dept. Of Medical Bioregulation Division Of Cardioventricular Medicine Yamaguchi University School Of
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