熱クリアランス曲線を用いた組織血流量の測定

概要

論文の詳細を見る
We have devised a new blood flow measurement apparatus based on thermal diffusion method, which was hardly affected by environmental temperature by means of using the thermal clearance curve with its baseline correted before each measurement. Fundamental studies concerning to finger blood flow measurement were carried out.The gradient of thermal clearance curve did not show significant changes in various water temperatures. This result indicated that effects of environmental temperature on thermal clearance curve were almost removed.The gradient of thermal clearance curve changed in parallele with the finger ischemia and hyperemia induced by inflation of a tourniquet. There was good reproducibility in continuous measurements.A highly significant positive correlation was obtained between finger blood flow measured by the inhaled hydrogen clearance method and the gradient of thermal clearance curve, indicating it possible to assess finger blood quantitatively by the gradient of thermal clearance curve.It was concluded that this new thermal diffusion method calibrated previously by the inhaled hydrogen clearance method enabled us to measure finger blood flow noninvasively under various conditions of temperature and was useful for diagnosis and research in various medical fields.
日本医療機器学会の論文
1989-11-01