自動血液分離装置KL-120の開発と評価

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A new type automatic blood separator for preparing blood products was developed and evaluated. The separtor, KL-120,was framed to reduce complicated operations for preparing buffy coat poor red cell concentrat(BPRCC), and to make standardized blood products.It has not only parallel pressure system to press centrifuged whole blood bag but vacuum suction system for absorbing fresh plasma(FP)and/or buffy coat(BC). As both system can work at the same time, the time to separate FP and BC from centrifuged whole blood was shortened. It has another aotomatic systems, breaking click tips and sealing tubings.We prepared BPRCC(BPRCC-200), platelet concentrate(PC-200)and FP(FP-200)from whole blood which derived from 200 ml of collected blood by this separator(n=10). Red cell recovery, white cell and platelet reduction in BPRCC were 87.1±2.1%, 64.4±4.7%, 82.0±4.7%, respectively. Platelet recovery of PC was 40.0±4.9% to whole blood, and 95.4±6.2ml of FP was obtained.We prepared BPRCC(BPRCC-400), platelet concentrate(PC-400)and FP(FP-400)from whole blood which derived from 400 ml of collected blood by this separator(n=20). Red cell recovery, white cell and platelet reduction in BPRCC were 87.6±1.3%, 66.3±705%, 87.0±6.3%, respectively. Platelet recovery of PC was 41.4±4.5% to whole blood, and 198.2±10.6ml of FP was obtained. The separation time for primary separation, preparing BPRCC-200,FP-200 and BC-200 from whole blood, was 72.8±2.8% seconds(n=13), and for secondary separation, PC from BC and sealing, was more than 23.1±1.1 seconds(n=13).The separation time for primary separation, preparing BPRCC-400,FP-400 and BC-400 from whole blood, was 90.0±2.9% seconds(n=13), and for secondary separation, PC from BC and sealing, was more than 23.0±1.2 seconds(n=13).From our experiments, comparing with manual preparation, this separator has some advantages, stable separation capacity and smooth operations. Thus, we conclude thae this separator is possible to prepare blood components(BPRCC, plasma, PC)from the whole blood with high efficiency and should contribute to eliminate the tedious work and to save labor time in blood centers.
日本医療機器学会の論文
1992-08-01

自動血液分離装置KL-120の開発と評価

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