非血縁者間末梢血幹細胞移植のためのドナーサイタフェレシスの展望

概要

論文の詳細を見る
Although unrelated peripheral blood-stem cell transplantation (PBSCT) is an attractive therapy for patients with severe hematological disorders, the safety of the healthy donor is crucial. To overcome related problems, there are some points to be discussed. The first point is the need to establish an optimal schedule for the administration of granulocyte colony-stimulating factor (G-CSF) in consideration of the effect of mobilization and the adverse effects to donors. However, to establish the schedule, the minimum requirement of CD34^+ cells for allogeneic PBSCT must be determined. The second point is to make a suitable protocol for leukapheresis. Because the response to G-CSF varies from donor to donor and the body weight is different between the donor and patient, especially in unrelated setting, an individual protocol for each donor is desirable to minimize the side effects. In this article, we introduce recent reports on the collection of PBSC from healthy donors and allogeneic PBSCT, including our experiences for autologous and allogeneic PBSCT, and discuss the possibility for unrelated PBSCT.
日本アフェレシス学会の論文
1998-02-28