3.単癌ウサギに於ける補体の動態(第3回補体シンポジウム III 補体とその関連領域)

概要

論文の詳細を見る
Although complement levels in the serum of tumor-bearing humans have been investigated in these recent years it has not been possible to compare complement levels before and after tumor-induction in a single subject, and the objective interpretation of the findings has not been feasible. Immunological experiments employing Shope papilloma-carcinoma system are now being carried out in our group. In the present paper we report our findings on the alteration of complement value (C'H_<50>) in the tumor-bearing rabbit, which were transplanted with carcinoma (ca) V×2, and (ca) V×7, both being neoplasia of Shope papilloma origin. The optimum assay condition of C'H_<50> in the serum of normal rabbits and tumor-bearing rabbits was in 2.5% glucose veronal buffer saline containing Ca^<++>(0.00015M), Mg^<++>(0.0005M), and 0.01% gelatin, at pH 7.4. C'H_<50> among the rabbits before tumor transplantation was on the average 9(15 cases out of 18 cases). This value inereases 9 fold steadily along with the increase in tumor size. Three cases, however, showed a high C'H value (20-40) from the beginning, and one case of the three followed a typical process of transplanted tumor, ie., a decrease of complement. Complement level of the rest did not vary until the death of these tumor bearing rabbits. Among the 6 cases of transplanted ca V×7, the C'H_<50> value of 10 before transplantation increased 5 folds showing a similar tendency as caV×2. Although caV×2 has elapsed 190 to 200 generations and caV×7 has elapsed 90 to 100 generations respecrively, and both tumors had been transplanted in thigh-muscles, they still retain histological characteristics as skin cancer (squamous cell carcinoma with central keratinous nests). Investigation of this increase of complment level is now under way in connection with variation in complement components and relation between tumor and host.
1966-11-30

3.単癌ウサギに於ける補体の動態(第3回補体シンポジウム III 補体とその関連領域)

スポンサーリンク

概要

著者

関連論文

スポンサーリンク