小児気管支喘息におけるヒスタミン固定能およびセロトニン固定能の研究

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The authors examined the histaminopexy and the serotoninopexy of nornal and asthmatic children in both the periods of the attacks and intervals. Moreover, we used Histaglobin for treatment and examined the histaminopexy and the serotoninopexy before and after the treatment. The refection limits of histaminopexy of 13 health children were 53.5 ± 26.5%, and we decided the value over 27% to be normal. The rejection limits of serotoninopexy of 23 healthy children were 41.5 ± 27%, and we decided the value over 15% to be normal. The histaminopexy of asthmatic children showed a considerable low in both attacks ant intervals, the average of which was 12% and the value of about half cases was less than 5%. The serotoninopexy of the same cases showed no significant difference from that of health children. However, in the period of attacks, it showed less than 5% in 1/3 cases of them. We investigated the reciprocity of the histaminopexy and serotoninopexy in asthmatic children. No reciprocity was observed, and it showed no difference from the stage of asthma. The authors examined the histaminopexy before and after 3-10 times of Histaglobin treatment and 1-2 months after treatment; no increase of histaminopexy was observed. We also examined the serotoninopexy of the same cases, however, no significant change was observed. On condition that the 10 cases which showed effects of treatment were concerned, the serotoninopexy showed under the normal value in all cases, and the serotoninopexy of immediately after treatment showed no difference from that of before treatment; 8 cases out of 10 showed the normal value 1-2 months after the treatment. And we emphasized that Histaglobin is good for the treatment of bronchial asthma which shows a low value of serotoninopexy.
日本アレルギー学会の論文
1968-11-30

小児気管支喘息におけるヒスタミン固定能およびセロトニン固定能の研究

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