気管支喘息患者の切除肺における病理組織像と肺ヒスタミン値について

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In the resected lung of an asthmatic patient pathohistological examination and determination of histamine were performed. The fourty-two year old male, who had attacks of bronchial asthma since the age of thirty-six, received right upper lobectomy for pulmonary tuberculosis on May, 1964. Following observations were performed in the part of the resected lung, in which tuberculous lesion was not confirmed. Pathohistological findings: The mucous membrane of bronchi was somewhat full of folds and their lumen was narrowed. In more or less large bronchi cilia of epithelium were partly indistinct and cubical epithelia were scarcely found. The epithelia of smaller bronchi were generally cubic or flat. The basement membrane showed features of hypertrophy and hyalinization in some places and the submucosal layer was hypertrophic in general and homogeneous in part. The hypertrophy of muscle layer was striking. In the wall of bronchioli and also around them eosinophils infiltrated in groups with slight infiltration of such round cells as lymphocyte and plasmocyte. A small quantity of secretion, desquamated epithelia and eosinophils were found within lumina of bronchi. The lung was generally emphysematous, but in part atelectatic portions were seen. Alveolar walls were, as a whole, slightly hypertrophic and connective tissue was also somewhat proliferative. Infiltrations of eosinophils were seen in some places of alveolar septa. Elastic fibers were large and a lot of them were broken. Vascular walls were hypertrophic in general and phagocytes containing hemosiderin were seen diffusely or in groups in them. Histamine content: Histamine of the lung tissue was measured by McIntire's method. The histamine contents of healthy portions in resected lungs of three patients with pulmonary tuberculosis were measured as controls and the average value of them was 29.8γ/g. The histamine content of the resected lung in the present patient was 79.5γ/g. Thus it was suggested that the histamine content of lung tissue of asthmatic patient was much increased as compared with that of non-asthmatics.
日本アレルギー学会の論文
1966-01-30

気管支喘息患者の切除肺における病理組織像と肺ヒスタミン値について

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