ストレス時における胃液分泌について

概要

論文の詳細を見る
An exact pathogenetic mechanism of peptic ulcer is still unknown. An emotional strees is considered to be one of the causing factors in the development of peptic ulcer. In this paper the effect of emotional strees on a secretion of gastric juice was investigated. A rat was used as an experimental animal and restricition or hunger were used as the methods of strees. The methods of Renaud, Kamitoshi or Bonfils were adopted as those of restriction. Histamine chloride or compound 48/80 was administered subcutaneously in the control group. The number of degranulated mast cells, and histamine content of grandular stomach and pH of gastric juice were measured in both stress loading and control groups. An increase in the number of degranulated mast cells and histamine content of grandular stomach and a decrease in the pH of gastric juice were observed after loading of emotional strees and histamine chloride or compound 48/80 injection in both groups. On the basis of these finding it is consiedered that the secretion of gastric juice is closely related to the degranulated mast cells and histamine content of the grandular stomach. Therefore the emotional stress is thought to have an important role on the development of peptic ulcer.
日本心身医学会の論文
1973-12-01