脳血管障害患者の下垂体前葉機能

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Prolactin (PRL) secretion in response to TRH was studied in patients with cerebrovascular diseases in order to elucidate the influence of cerebrovascular lesions on the hypothalamus-anterior pituitary function. <BR>Blood specimens were obtained before and at intervals of 10, 20, 30, 40, 60, 90 and 120 minutes after the intravenous administration of 500 μg of TRH. Serum PRL was measured using the RIA method. <BR>In 18 normal subjects, the serum PRL level before TRH administration was 9.7±1.7 ng/ml (MEAN±SD). Following the intravenous administration of TRH, serum PRL increased and reached the maximum level of 34.3±15.9 ng/ml at 20 minutes and returned near to the original level at 120 minutes. PRL levels in the female were slightly higher than those in the male. <BR>In 17 patients with cerebral hemorrhage, a marked variability of the response of PRL to TRH was observed in each case. In female cases, the response of PRL to TRH was generally high as compared with that in male cases. In female patients the response was fairly good, even though serum PRL levels before TRH administration were high. On the other hand, a poor response was observed in severe male cases, whose PRL levels before administration were high. <BR>In 8 patients with cerebral infarction, the response of PRL to TRH was nearly normal although the response was slightly delayed. In the patients with cerebral infarction, the response of TSH to TRH was low in all cases; that is, as in the previous paper, a dissociation between TSH and PRL response to TRH was observed. TSH and PRL response to TRH in patients with cerebrovascular diseases also suggested that PRL secretion was less impaired as compared with TSH secretion.

脳血管障害患者の下垂体前葉機能

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