Effects of Potato Kallikrein Inhibitor and S-Methyl-L-Cysteine Sulfoxide on Plasma and Liver Kininogen Levels of X-irradiated Rats and Effectiveness of these Materials as Radioprotectors

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The effect of radiation on kininogen (a precursor of physiologically active peptides, kinins) levels in plasma and liver was investigated. Male rats were exposed to 700 R of X-rays. The kininogen level showed 10-fold elevation in four hours after irradiation and then rapidly returned to the normal value. Effects of liver-protecting compounds, such as PKI (Potato Kallikrein Inhibitor) and MET (S-methyl-L-cysteine sulfoxide), on radiation-induced elevation of kininogen levels in plasma and liver were then investigated. The elevation was strongly suppressed when the animals were treated with these compounds. When tested in mice, these compounds were effective in extending survival time after X-irradiation of 700 R.
日本放射線影響学会の論文