放射線障害防護薬剤に関する研究(第4報) : ビタミンEおよびその誘導体の放射線障害防護効力について
スポンサーリンク
概要
- 論文の詳細を見る
This experiment was undertaken to determine the radioprotective activity of vitamin E and its esterified derivatives, using survival time and body weight changes in X-irradiated mice as the pharmacological indices. Male mice of ddY strain, 5 to 6 weeks old, were used in this experiment. Each group consisting of 10 mice was exposed to 700 R whole body X-irradiation, which caused 100% mortality of the mice without medication within 2 weeks after X-irradiation under the condition adopted for this experiment. The test preparations such as vitamin E, and its acetate, ferulate, caffeate, and succinate were dissolved in sesame oil or cottonseed oil, or suspended in 5% Tween 80 aqueous solution, and administered intraperitoneally 24 or 3 hr. before the irradiation or 5 min after irradiation ; 1 mmole/kg of vitamin E, acetate or ferulate, 0.5 mmole/kg of the caffeate, or 0.25 mmole/kg of the succinate. The potency of radioprotective effect of each preparation was evaluated, based on the elongation of survival time up to 30 days and increase in body weight two weeks after irradiation, comparing with the control. Tween 80,used as the detergent to emulsify the preparation, did not show any influence on survival time and body weight. Sesame oil was slightly radioprotective on survival time and body weight. Cottonseed oil caused decrease in body weight under a certain circumstance. Under the condition of this experiment, vitamin E was little effective, while the acetate was slightly effective, and the other esters were significantly effective, and it was found that radioprotective effect was increased by esterification of vitamin E. It was also found that estimates of the effect based on survival time and on body weight were agreement. Radioprotective effect of the preparations seemed to depend the solvent used and the time of administration.
- 公益社団法人日本薬学会の論文
- 1968-03-25
著者
関連論文
- Radioprotective Effect of Pyridoxamine-5-thiophosphate and Related Compounds
- 放射線障害防護薬剤に関する研究(第15報)インドール系化合物の放射線障害防護効力について
- 放射線障害防護薬剤に関する研究(第8報)システアミン関連化合物の放射線障害防護効力について
- 放射線障害防護薬剤に関する研究(第7報) : AETおよびその関連化合物の放射線障害防護効力について
- Serum Levels of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) in Subjects Accidentally Exposed to ^Ir Gamma rays
- Effects of Potato Kallikrein Inhibitor and S-Methyl-L-Cysteine Sulfoxide on Plasma and Liver Kininogen Levels of X-irradiated Rats and Effectiveness of these Materials as Radioprotectors
- Therapeutic Effect of Tetrahydrofolic Acid in Midlethally X-Irradiated Mice
- 放射線障害防護薬剤に関する研究(第17報)フェネチラミン系化合物の放射線障害防護効力について
- Increase of Survival of X-Irradiated Mice by Postirradiation Injections of a Splenic Extract Prepared from Vaccine or Endotoxin-treated Syngenic Animals
- 放射線障害防護薬剤に関する研究(第14報)含イオウ化合物の放射線障害防護効力について
- 放射線障害防護薬剤に関する研究(第13報)放射線によるマウスの臓器重量の変化ならびに放射線障害防護物質の効果について
- Hypotensive and Radioprotective Properties of N^6-Substituted Adenosine Derivatives
- Radioprotective Potency of Thiazine and Thiazole Derivatives
- Radioprotective Effect of Sodium Hydrogen S-(2-L-Pyrrolidyl-methyl) phosphorothioate in Mice
- Durable Radioprotection by Oral Administration of 2-Aminoethanethiosulfuric Acid in Mice
- 放射線障害防護薬剤に関する研究(第6報) : 放射線によるマウスの体重変化を指標とする放射線障害防護薬剤の効力試験法の検討
- Radiation Protection of Mice by Mixtures of β-Mercaptoethylguanidine (MEG) and Cysteamine (MEA)
- Protection of Catalase from Radiation-inactivation by Adenosine and its Derivatives in Dilute Solution
- 放射線障害防護薬剤に関する研究(第4報) : ビタミンEおよびその誘導体の放射線障害防護効力について
- パロチンおよびS-パロチンによる白血球増加作用の検討
- サリバ・パロチン・Aによる白血球増加作用の検討
- サリバ・パロチン・Aの抗原性について
- β-subunit hCGのRadioimmunoassayによるヒト着床期より分娩後にいたる血中hCGの動態
- イモリ睾丸における雄性ホルモンの生合成(内分泌・生化学)
- 放射線障害防護薬剤に関する研究(第5報) : マウスによる放射線障害防護薬剤の効力試験法の検討
- 放射線障害防護薬剤に関する研究(第3報) : AETおよびMEAの放射線障害防護効力について
- 放射線障害防護薬剤に関する研究(第2報) : 放射線によるマウス体重の変化について
- 放射線障害防護薬剤に関する研究(第1報) : 放射線によるマウスの致死効果について
- Radiation Protection by Oral Administration of L-Cysteine Ethyl Ester Hydrochloride in Mice
- 放射線障害防護物質について
- 分子レベルからみた放射線障害と防護