放射線障害防護薬剤に関する研究(第1報) : 放射線によるマウスの致死効果について

概要

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In order to establish the potency test for chemical radiation protectors, radiosensitivity of various strains of mice to X-ray irradiation was examined. The mice used were ddY, CF_1,and CRF_1 strainrs, and it was found that the survival rate 30 days after irradiation and the mean survival time were both effective indices of radiation injury. Since the variation in radiation dosage, and the strain and age of mice affected the radiosensitivity, optical conditions for biological assay of chemical radiation protectors were determined as follows. When using ddY strain mice, those of 4〜7 weeks of age should be used and given X-ray irradiation of 700R. With CRF_1 strain mice, 600 R dose seems to be appropriate. In the case of CF_1 strain mice, radiation dosage and variation in survival rate failed to show linearity and this strain of mice is considered to be unsuitable for this biological assay.
公益社団法人日本薬学会の論文
1967-06-25