抗炎症薬の作用形式の研究(第1報) : Carboxymethyl cellulose嚢法による抗炎症作用の定量的解析

概要

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A new method has been established by which the time course of the vascular permeability increase and leucocyte emigration in the exudative inflammation can be traced on individual animals with the aid of carboxymethyl cellulose as an inflammatory agent. This method provides useful meansto evaluate the characteristics of anti-inflammatory agents. By this method, the mode of action of steroidal and non-steroidal anti-inflammatory agents was studied and results were are as follows : 1) There is a lag phase of three hours in the leucocyte emigration. 2) Steroids strongly inhibited the emigration of leucocyte into the experimental inflammatory locus. The inhibitory effect increased gradually with lapse of time. Non-steroidal anti-inflammatory agents, like Indomethacin, and salicylic acid inhibited the leucocyte emigration at a nearly constant rate. 3) The inhibitory effect on the vascular permeability was comparatively weak with the steroidal anti-inflammatory agents except sodium betamethasone phosphate, while Phenylbutazone and Indomethacin gave a moderate suppresive effect.
社団法人日本薬学会の論文
1968-11-25